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Review of functional magnetic resonance imaging in the assessment of nasopharyngeal carcinoma treatment response

Publication ,  Journal Article
Wong, KL; Cheng, KH; Lam, SK; Liu, C; Cai, J
Published in: Precision Radiation Oncology
June 1, 2022

Nasopharyngeal carcinoma (NPC) is a common malignancy endemic in South-East Asia. Functional magnetic resonance imaging (fMRI) has been used for prompt detection of treatment response before visible morphological changes in NPC treatment. Among different fMRI techniques, diffusion-weighted imaging (DWI) and dynamic contrast enhancement (DCE) were proved to be more successful in NPC treatment response assessment whilst the application of magnetic resonance spectroscopy (MRS) remains questionable. Apart from discussing the imaging technique, time points for post-treatment response assessments are recommended. Four instead of three months is recommended for prompt identification of non- or partial responders and 6–9 months post-treatment multiparametric MRI is also recommended for effective confirmation of complete responding individuals to avoid residual disease. For future advancement, in addition to the post-treatment response assessment, continuous or longitudinal assessment on the treatment response with the use of magnetic resonance simulator (MR-simulator) or magnetic resonace imaging guided linear accelerator (MR-Linac) tailor-made for radiotherapy (RT) maybe feasible. Longitudinal assessments or predictive radiomics modeling allow spotting out the possibility of treatment failure before the completion or even before the start of treatments. Adaptive instead of salvage treatments can then be prepared, thus reducing the damage and side effects of consecutive cytotoxic treatments.

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Published In

Precision Radiation Oncology

DOI

EISSN

2398-7324

Publication Date

June 1, 2022

Volume

6

Issue

2

Start / End Page

177 / 185
 

Citation

APA
Chicago
ICMJE
MLA
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Wong, K. L., Cheng, K. H., Lam, S. K., Liu, C., & Cai, J. (2022). Review of functional magnetic resonance imaging in the assessment of nasopharyngeal carcinoma treatment response. Precision Radiation Oncology, 6(2), 177–185. https://doi.org/10.1002/pro6.1161
Wong, K. L., K. H. Cheng, S. K. Lam, C. Liu, and J. Cai. “Review of functional magnetic resonance imaging in the assessment of nasopharyngeal carcinoma treatment response.” Precision Radiation Oncology 6, no. 2 (June 1, 2022): 177–85. https://doi.org/10.1002/pro6.1161.
Wong KL, Cheng KH, Lam SK, Liu C, Cai J. Review of functional magnetic resonance imaging in the assessment of nasopharyngeal carcinoma treatment response. Precision Radiation Oncology. 2022 Jun 1;6(2):177–85.
Wong, K. L., et al. “Review of functional magnetic resonance imaging in the assessment of nasopharyngeal carcinoma treatment response.” Precision Radiation Oncology, vol. 6, no. 2, June 2022, pp. 177–85. Scopus, doi:10.1002/pro6.1161.
Wong KL, Cheng KH, Lam SK, Liu C, Cai J. Review of functional magnetic resonance imaging in the assessment of nasopharyngeal carcinoma treatment response. Precision Radiation Oncology. 2022 Jun 1;6(2):177–185.

Published In

Precision Radiation Oncology

DOI

EISSN

2398-7324

Publication Date

June 1, 2022

Volume

6

Issue

2

Start / End Page

177 / 185