18F-FDG PET/CT Staging of Head and Neck Cancer: Interobserver Agreement and Accuracy-Results from Multicenter ACRIN 6685 Clinical Trial.
To our knowledge, no prior multicenter clinical trial has reported interobserver agreement of 18F-FDG PET/CT scans for staging of clinical N0 neck in head and neck cancer. Methods: A total of 287 participants were recruited. For visual analysis, positive nodal uptake of 18F-FDG was defined as uptake visually greater than activity seen in the blood pool. Results: The negative predictive value of the 18F-FDG PET/CT for N0 clinical neck was 86% or above for visual assessment (95% CI, 86%-88%) for the 2 central readers and above 90% (95% CI, 90%-95%) for SUVmax for central reads and site reads dichotomized at the optimal cutoff value of 1.8 and the prespecified cutoff value of 3.5, respectively. The κ coefficients between the 2 expert readers and between central reads and site reads varied between 0.53 and 0.78. Conclusion: The NPV of the 18F-FDG PET/CT for N0 clinical neck was 86% or above for visual assessment and above 90% for SUVmax cut points of 1.8 and 3.5 with moderate to substantial agreements.
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- Tomography, X-Ray Computed
- Radiopharmaceuticals
- Positron Emission Tomography Computed Tomography
- Observer Variation
- Nuclear Medicine & Medical Imaging
- Neoplasm Staging
- Humans
- Head and Neck Neoplasms
- Fluorodeoxyglucose F18
- 3202 Clinical sciences
Citation
Published In
DOI
EISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- Tomography, X-Ray Computed
- Radiopharmaceuticals
- Positron Emission Tomography Computed Tomography
- Observer Variation
- Nuclear Medicine & Medical Imaging
- Neoplasm Staging
- Humans
- Head and Neck Neoplasms
- Fluorodeoxyglucose F18
- 3202 Clinical sciences