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18F-FDG PET/CT Staging of Head and Neck Cancer: Interobserver Agreement and Accuracy-Results from Multicenter ACRIN 6685 Clinical Trial.

Publication ,  Journal Article
Subramaniam, RM; Duan, FM; Romanoff, J; Yu, JQ; Bartel, T; Dehdashti, F; Intenzo, CM; Solnes, L; Sicks, J; Stack, BC; Lowe, VJ
Published in: J Nucl Med
December 2022

To our knowledge, no prior multicenter clinical trial has reported interobserver agreement of 18F-FDG PET/CT scans for staging of clinical N0 neck in head and neck cancer. Methods: A total of 287 participants were recruited. For visual analysis, positive nodal uptake of 18F-FDG was defined as uptake visually greater than activity seen in the blood pool. Results: The negative predictive value of the 18F-FDG PET/CT for N0 clinical neck was 86% or above for visual assessment (95% CI, 86%-88%) for the 2 central readers and above 90% (95% CI, 90%-95%) for SUVmax for central reads and site reads dichotomized at the optimal cutoff value of 1.8 and the prespecified cutoff value of 3.5, respectively. The κ coefficients between the 2 expert readers and between central reads and site reads varied between 0.53 and 0.78. Conclusion: The NPV of the 18F-FDG PET/CT for N0 clinical neck was 86% or above for visual assessment and above 90% for SUVmax cut points of 1.8 and 3.5 with moderate to substantial agreements.

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Published In

J Nucl Med

DOI

EISSN

1535-5667

Publication Date

December 2022

Volume

63

Issue

12

Start / End Page

1887 / 1890

Location

United States

Related Subject Headings

  • Tomography, X-Ray Computed
  • Radiopharmaceuticals
  • Positron Emission Tomography Computed Tomography
  • Observer Variation
  • Nuclear Medicine & Medical Imaging
  • Neoplasm Staging
  • Humans
  • Head and Neck Neoplasms
  • Fluorodeoxyglucose F18
  • 3202 Clinical sciences
 

Citation

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Subramaniam, R. M., Duan, F. M., Romanoff, J., Yu, J. Q., Bartel, T., Dehdashti, F., … Lowe, V. J. (2022). 18F-FDG PET/CT Staging of Head and Neck Cancer: Interobserver Agreement and Accuracy-Results from Multicenter ACRIN 6685 Clinical Trial. J Nucl Med, 63(12), 1887–1890. https://doi.org/10.2967/jnumed.122.263902
Subramaniam, Rathan M., Fenghai M. Duan, Justin Romanoff, Jian Qin Yu, Twyla Bartel, Farrokh Dehdashti, Charles M. Intenzo, et al. “18F-FDG PET/CT Staging of Head and Neck Cancer: Interobserver Agreement and Accuracy-Results from Multicenter ACRIN 6685 Clinical Trial.J Nucl Med 63, no. 12 (December 2022): 1887–90. https://doi.org/10.2967/jnumed.122.263902.
Subramaniam RM, Duan FM, Romanoff J, Yu JQ, Bartel T, Dehdashti F, et al. 18F-FDG PET/CT Staging of Head and Neck Cancer: Interobserver Agreement and Accuracy-Results from Multicenter ACRIN 6685 Clinical Trial. J Nucl Med. 2022 Dec;63(12):1887–90.
Subramaniam, Rathan M., et al. “18F-FDG PET/CT Staging of Head and Neck Cancer: Interobserver Agreement and Accuracy-Results from Multicenter ACRIN 6685 Clinical Trial.J Nucl Med, vol. 63, no. 12, Dec. 2022, pp. 1887–90. Pubmed, doi:10.2967/jnumed.122.263902.
Subramaniam RM, Duan FM, Romanoff J, Yu JQ, Bartel T, Dehdashti F, Intenzo CM, Solnes L, Sicks J, Stack BC, Lowe VJ. 18F-FDG PET/CT Staging of Head and Neck Cancer: Interobserver Agreement and Accuracy-Results from Multicenter ACRIN 6685 Clinical Trial. J Nucl Med. 2022 Dec;63(12):1887–1890.

Published In

J Nucl Med

DOI

EISSN

1535-5667

Publication Date

December 2022

Volume

63

Issue

12

Start / End Page

1887 / 1890

Location

United States

Related Subject Headings

  • Tomography, X-Ray Computed
  • Radiopharmaceuticals
  • Positron Emission Tomography Computed Tomography
  • Observer Variation
  • Nuclear Medicine & Medical Imaging
  • Neoplasm Staging
  • Humans
  • Head and Neck Neoplasms
  • Fluorodeoxyglucose F18
  • 3202 Clinical sciences