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Metal dependent protein phosphatase PPM family in cardiac health and diseases.

Publication ,  Journal Article
Gao, C; Cao, N; Wang, Y
Published in: Cell Signal
September 2021

Protein phosphorylation and dephosphorylation is central to signal transduction in nearly every aspect of cellular function, including cardiovascular regulation and diseases. While protein kinases are often regarded as the molecular drivers in cellular signaling with high specificity and tight regulation, dephosphorylation mediated by protein phosphatases is also gaining increasing appreciation as an important part of the signal transduction network essential for the robustness, specificity and homeostasis of cell signaling. Metal dependent protein phosphatases (PPM, also known as protein phosphatases type 2C, PP2C) belong to a highly conserved family of protein phosphatases with unique biochemical and molecular features. Accumulating evidence also indicates important and specific functions of individual PPM isoform in signaling and cellular processes, including proliferation, senescence, apoptosis and metabolism. At the physiological level, abnormal PPM expression and activity have been implicated in major human diseases, including cancer, neurological and cardiovascular disorders. Finally, inhibitors for some of the PPM members have been developed as a potential therapeutic strategy for human diseases. In this review, we will focus on the background information about the biochemical and molecular features of major PPM family members, with emphasis on their demonstrated or potential roles in cardiac pathophysiology. The current challenge and potential directions for future investigations will also be highlighted.

Duke Scholars

Published In

Cell Signal

DOI

EISSN

1873-3913

Publication Date

September 2021

Volume

85

Start / End Page

110061

Location

England

Related Subject Headings

  • Signal Transduction
  • Protein Phosphatase 2C
  • Protein Phosphatase 2
  • Phosphorylation
  • Phosphoprotein Phosphatases
  • Humans
  • Biochemistry & Molecular Biology
  • 3101 Biochemistry and cell biology
  • 1116 Medical Physiology
  • 0601 Biochemistry and Cell Biology
 

Citation

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Gao, C., Cao, N., & Wang, Y. (2021). Metal dependent protein phosphatase PPM family in cardiac health and diseases. Cell Signal, 85, 110061. https://doi.org/10.1016/j.cellsig.2021.110061
Gao, Chen, Nancy Cao, and Yibin Wang. “Metal dependent protein phosphatase PPM family in cardiac health and diseases.Cell Signal 85 (September 2021): 110061. https://doi.org/10.1016/j.cellsig.2021.110061.
Gao C, Cao N, Wang Y. Metal dependent protein phosphatase PPM family in cardiac health and diseases. Cell Signal. 2021 Sep;85:110061.
Gao, Chen, et al. “Metal dependent protein phosphatase PPM family in cardiac health and diseases.Cell Signal, vol. 85, Sept. 2021, p. 110061. Pubmed, doi:10.1016/j.cellsig.2021.110061.
Gao C, Cao N, Wang Y. Metal dependent protein phosphatase PPM family in cardiac health and diseases. Cell Signal. 2021 Sep;85:110061.
Journal cover image

Published In

Cell Signal

DOI

EISSN

1873-3913

Publication Date

September 2021

Volume

85

Start / End Page

110061

Location

England

Related Subject Headings

  • Signal Transduction
  • Protein Phosphatase 2C
  • Protein Phosphatase 2
  • Phosphorylation
  • Phosphoprotein Phosphatases
  • Humans
  • Biochemistry & Molecular Biology
  • 3101 Biochemistry and cell biology
  • 1116 Medical Physiology
  • 0601 Biochemistry and Cell Biology