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A risk score based on baseline risk factors for predicting mortality in COVID-19 patients.

Publication ,  Journal Article
Chen, Z; Chen, J; Zhou, J; Lei, F; Zhou, F; Qin, J-J; Zhang, X-J; Zhu, L; Liu, Y-M; Wang, H; Chen, M-M; Zhao, Y-C; Xie, J; Shen, L; Song, X ...
Published in: Curr Med Res Opin
June 2021

BACKGROUND: To develop a sensitive and clinically applicable risk assessment tool identifying coronavirus disease 2019 (COVID-19) patients with a high risk of mortality at hospital admission. This model would assist frontline clinicians in optimizing medical treatment with limited resources. METHODS: 6415 patients from seven hospitals in Wuhan city were assigned to the training and testing cohorts. A total of 6351 patients from another three hospitals in Wuhan, 2169 patients from outside of Wuhan, and 553 patients from Milan, Italy were assigned to three independent validation cohorts. A total of 64 candidate clinical variables at hospital admission were analyzed by random forest and least absolute shrinkage and selection operator (LASSO) analyses. RESULTS: Eight factors, namely, Oxygen saturation, blood Urea nitrogen, Respiratory rate, admission before the date the national Maximum number of daily new cases was reached, Age, Procalcitonin, C-reactive protein (CRP), and absolute Neutrophil counts, were identified as having significant associations with mortality in COVID-19 patients. A composite score based on these eight risk factors, termed the OURMAPCN-score, predicted the risk of mortality among the COVID-19 patients, with a C-statistic of 0.92 (95% confidence interval [CI] 0.90-0.93). The hazard ratio for all-cause mortality between patients with OURMAPCN-score >11 compared with those with scores ≤ 11 was 18.18 (95% CI 13.93-23.71; p < .0001). The predictive performance, specificity, and sensitivity of the score were validated in three independent cohorts. CONCLUSIONS: The OURMAPCN score is a risk assessment tool to determine the mortality rate in COVID-19 patients based on a limited number of baseline parameters. This tool can assist physicians in optimizing the clinical management of COVID-19 patients with limited hospital resources.

Duke Scholars

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Published In

Curr Med Res Opin

DOI

EISSN

1473-4877

Publication Date

June 2021

Volume

37

Issue

6

Start / End Page

917 / 927

Location

England

Related Subject Headings

  • Risk Factors
  • Risk Assessment
  • Italy
  • Humans
  • Hospitalization
  • General & Internal Medicine
  • China
  • COVID-19
  • 4003 Biomedical engineering
  • 3206 Medical biotechnology
 

Citation

APA
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ICMJE
MLA
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Chen, Z., Chen, J., Zhou, J., Lei, F., Zhou, F., Qin, J.-J., … Li, H. (2021). A risk score based on baseline risk factors for predicting mortality in COVID-19 patients. Curr Med Res Opin, 37(6), 917–927. https://doi.org/10.1080/03007995.2021.1904862
Chen, Ze, Jing Chen, Jianghua Zhou, Fang Lei, Feng Zhou, Juan-Juan Qin, Xiao-Jing Zhang, et al. “A risk score based on baseline risk factors for predicting mortality in COVID-19 patients.Curr Med Res Opin 37, no. 6 (June 2021): 917–27. https://doi.org/10.1080/03007995.2021.1904862.
Chen Z, Chen J, Zhou J, Lei F, Zhou F, Qin J-J, et al. A risk score based on baseline risk factors for predicting mortality in COVID-19 patients. Curr Med Res Opin. 2021 Jun;37(6):917–27.
Chen, Ze, et al. “A risk score based on baseline risk factors for predicting mortality in COVID-19 patients.Curr Med Res Opin, vol. 37, no. 6, June 2021, pp. 917–27. Pubmed, doi:10.1080/03007995.2021.1904862.
Chen Z, Chen J, Zhou J, Lei F, Zhou F, Qin J-J, Zhang X-J, Zhu L, Liu Y-M, Wang H, Chen M-M, Zhao Y-C, Xie J, Shen L, Song X, Zhang X, Yang C, Liu W, Guo D, Yan Y, Liu M, Mao W, Liu L, Ye P, Xiao B, Luo P, Zhang Z, Lu Z, Wang J, Lu H, Xia X, Wang D, Liao X, Peng G, Liang L, Yang J, Chen G, Azzolini E, Aghemo A, Ciccarelli M, Condorelli G, Stefanini GG, Wei X, Zhang B-H, Huang X, Xia J, Yuan Y, She Z-G, Guo J, Wang Y, Zhang P, Li H. A risk score based on baseline risk factors for predicting mortality in COVID-19 patients. Curr Med Res Opin. 2021 Jun;37(6):917–927.

Published In

Curr Med Res Opin

DOI

EISSN

1473-4877

Publication Date

June 2021

Volume

37

Issue

6

Start / End Page

917 / 927

Location

England

Related Subject Headings

  • Risk Factors
  • Risk Assessment
  • Italy
  • Humans
  • Hospitalization
  • General & Internal Medicine
  • China
  • COVID-19
  • 4003 Biomedical engineering
  • 3206 Medical biotechnology