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In-Hospital Use of Statins Is Associated with a Reduced Risk of Mortality among Individuals with COVID-19.

Publication ,  Journal Article
Zhang, X-J; Qin, J-J; Cheng, X; Shen, L; Zhao, Y-C; Yuan, Y; Lei, F; Chen, M-M; Yang, H; Bai, L; Song, X; Lin, L; Xia, M; Zhou, F; Zhou, J ...
Published in: Cell Metab
August 4, 2020

Statins are lipid-lowering therapeutics with favorable anti-inflammatory profiles and have been proposed as an adjunct therapy for COVID-19. However, statins may increase the risk of SARS-CoV-2 viral entry by inducing ACE2 expression. Here, we performed a retrospective study on 13,981 patients with COVID-19 in Hubei Province, China, among which 1,219 received statins. Based on a mixed-effect Cox model after propensity score-matching, we found that the risk for 28-day all-cause mortality was 5.2% and 9.4% in the matched statin and non-statin groups, respectively, with an adjusted hazard ratio of 0.58. The statin use-associated lower risk of mortality was also observed in the Cox time-varying model and marginal structural model analysis. These results give support for the completion of ongoing prospective studies and randomized controlled trials involving statin treatment for COVID-19, which are needed to further validate the utility of this class of drugs to combat the mortality of this pandemic.

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Published In

Cell Metab

DOI

EISSN

1932-7420

Publication Date

August 4, 2020

Volume

32

Issue

2

Start / End Page

176 / 187.e4

Location

United States

Related Subject Headings

  • SARS-CoV-2
  • Retrospective Studies
  • Pneumonia, Viral
  • Peptidyl-Dipeptidase A
  • Pandemics
  • Middle Aged
  • Male
  • Hypertension
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors
  • Humans
 

Citation

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Zhang, X.-J., Qin, J.-J., Cheng, X., Shen, L., Zhao, Y.-C., Yuan, Y., … Li, H. (2020). In-Hospital Use of Statins Is Associated with a Reduced Risk of Mortality among Individuals with COVID-19. Cell Metab, 32(2), 176-187.e4. https://doi.org/10.1016/j.cmet.2020.06.015
Zhang, Xiao-Jing, Juan-Juan Qin, Xu Cheng, Lijun Shen, Yan-Ci Zhao, Yufeng Yuan, Fang Lei, et al. “In-Hospital Use of Statins Is Associated with a Reduced Risk of Mortality among Individuals with COVID-19.Cell Metab 32, no. 2 (August 4, 2020): 176-187.e4. https://doi.org/10.1016/j.cmet.2020.06.015.
Zhang X-J, Qin J-J, Cheng X, Shen L, Zhao Y-C, Yuan Y, et al. In-Hospital Use of Statins Is Associated with a Reduced Risk of Mortality among Individuals with COVID-19. Cell Metab. 2020 Aug 4;32(2):176-187.e4.
Zhang, Xiao-Jing, et al. “In-Hospital Use of Statins Is Associated with a Reduced Risk of Mortality among Individuals with COVID-19.Cell Metab, vol. 32, no. 2, Aug. 2020, pp. 176-187.e4. Pubmed, doi:10.1016/j.cmet.2020.06.015.
Zhang X-J, Qin J-J, Cheng X, Shen L, Zhao Y-C, Yuan Y, Lei F, Chen M-M, Yang H, Bai L, Song X, Lin L, Xia M, Zhou F, Zhou J, She Z-G, Zhu L, Ma X, Xu Q, Ye P, Chen G, Liu L, Mao W, Yan Y, Xiao B, Lu Z, Peng G, Liu M, Yang J, Yang L, Zhang C, Lu H, Xia X, Wang D, Liao X, Wei X, Zhang B-H, Zhang X, Zhao G-N, Zhang P, Liu PP, Loomba R, Ji Y-X, Xia J, Wang Y, Cai J, Guo J, Li H. In-Hospital Use of Statins Is Associated with a Reduced Risk of Mortality among Individuals with COVID-19. Cell Metab. 2020 Aug 4;32(2):176-187.e4.
Journal cover image

Published In

Cell Metab

DOI

EISSN

1932-7420

Publication Date

August 4, 2020

Volume

32

Issue

2

Start / End Page

176 / 187.e4

Location

United States

Related Subject Headings

  • SARS-CoV-2
  • Retrospective Studies
  • Pneumonia, Viral
  • Peptidyl-Dipeptidase A
  • Pandemics
  • Middle Aged
  • Male
  • Hypertension
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors
  • Humans