Western Diet-Fed, Aortic-Banded Ossabaw Swine: A Preclinical Model of Cardio-Metabolic Heart Failure.
Publication
, Journal Article
Olver, TD; Edwards, JC; Jurrissen, TJ; Veteto, AB; Jones, JL; Gao, C; Rau, C; Warren, CM; Klutho, PJ; Alex, L; Ferreira-Nichols, SC; Ivey, JR ...
Published in: JACC Basic Transl Sci
June 2019
The development of new treatments for heart failure lack animal models that encompass the increasingly heterogeneous disease profile of this patient population. This report provides evidence supporting the hypothesis that Western Diet-fed, aortic-banded Ossabaw swine display an integrated physiological, morphological, and genetic phenotype evocative of cardio-metabolic heart failure. This new preclinical animal model displays a distinctive constellation of findings that are conceivably useful to extending the understanding of how pre-existing cardio-metabolic syndrome can contribute to developing HF.
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Published In
JACC Basic Transl Sci
DOI
EISSN
2452-302X
Publication Date
June 2019
Volume
4
Issue
3
Start / End Page
404 / 421
Location
United States
Related Subject Headings
- 3201 Cardiovascular medicine and haematology
- 1103 Clinical Sciences
- 1102 Cardiorespiratory Medicine and Haematology
Citation
APA
Chicago
ICMJE
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Olver, T. D., Edwards, J. C., Jurrissen, T. J., Veteto, A. B., Jones, J. L., Gao, C., … Emter, C. A. (2019). Western Diet-Fed, Aortic-Banded Ossabaw Swine: A Preclinical Model of Cardio-Metabolic Heart Failure. JACC Basic Transl Sci, 4(3), 404–421. https://doi.org/10.1016/j.jacbts.2019.02.004
Olver, T Dylan, Jenna C. Edwards, Thomas J. Jurrissen, Adam B. Veteto, John L. Jones, Chen Gao, Christoph Rau, et al. “Western Diet-Fed, Aortic-Banded Ossabaw Swine: A Preclinical Model of Cardio-Metabolic Heart Failure.” JACC Basic Transl Sci 4, no. 3 (June 2019): 404–21. https://doi.org/10.1016/j.jacbts.2019.02.004.
Olver TD, Edwards JC, Jurrissen TJ, Veteto AB, Jones JL, Gao C, et al. Western Diet-Fed, Aortic-Banded Ossabaw Swine: A Preclinical Model of Cardio-Metabolic Heart Failure. JACC Basic Transl Sci. 2019 Jun;4(3):404–21.
Olver, T. Dylan, et al. “Western Diet-Fed, Aortic-Banded Ossabaw Swine: A Preclinical Model of Cardio-Metabolic Heart Failure.” JACC Basic Transl Sci, vol. 4, no. 3, June 2019, pp. 404–21. Pubmed, doi:10.1016/j.jacbts.2019.02.004.
Olver TD, Edwards JC, Jurrissen TJ, Veteto AB, Jones JL, Gao C, Rau C, Warren CM, Klutho PJ, Alex L, Ferreira-Nichols SC, Ivey JR, Thorne PK, McDonald KS, Krenz M, Baines CP, Solaro RJ, Wang Y, Ford DA, Domeier TL, Padilla J, Rector RS, Emter CA. Western Diet-Fed, Aortic-Banded Ossabaw Swine: A Preclinical Model of Cardio-Metabolic Heart Failure. JACC Basic Transl Sci. 2019 Jun;4(3):404–421.
Published In
JACC Basic Transl Sci
DOI
EISSN
2452-302X
Publication Date
June 2019
Volume
4
Issue
3
Start / End Page
404 / 421
Location
United States
Related Subject Headings
- 3201 Cardiovascular medicine and haematology
- 1103 Clinical Sciences
- 1102 Cardiorespiratory Medicine and Haematology