Skip to main content
Journal cover image

p38α MAPK Regulates Lineage Commitment and OPG Synthesis of Bone Marrow Stromal Cells to Prevent Bone Loss under Physiological and Pathological Conditions.

Publication ,  Journal Article
Cong, Q; Jia, H; Biswas, S; Li, P; Qiu, S; Deng, Q; Guo, X; Ma, G; Ling Chau, JF; Wang, Y; Zhang, Z-L; Jiang, X; Liu, H; Li, B
Published in: Stem Cell Reports
April 12, 2016

Bone marrow-derived mesenchymal stromal cells (BM-MSCs) are capable of differentiating into osteoblasts, chondrocytes, and adipocytes. Skewed differentiation of BM-MSCs contributes to the pathogenesis of osteoporosis. Yet how BM-MSC lineage commitment is regulated remains unclear. We show that ablation of p38α in Prx1+ BM-MSCs produced osteoporotic phenotypes, growth plate defects, and increased bone marrow fat, secondary to biased BM-MSC differentiation from osteoblast/chondrocyte to adipocyte and increased osteoclastogenesis and bone resorption. p38α regulates BM-MSC osteogenic commitment through TAK1-NF-κB signaling and osteoclastogenesis through osteoprotegerin (OPG) production by BM-MSCs. Estrogen activates p38α to maintain OPG expression in BM-MSCs to preserve the bone. Ablation of p38α in BM-MSCs positive for Dermo1, a later BM-MSC marker, only affected osteogenic differentiation. Thus, p38α mitogen-activated protein kinase (MAPK) in Prx1+ BM-MSCs acts to preserve the bone by promoting osteogenic lineage commitment and sustaining OPG production. This study thus unravels previously unidentified roles for p38α MAPK in skeletal development and bone remodeling.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Stem Cell Reports

DOI

EISSN

2213-6711

Publication Date

April 12, 2016

Volume

6

Issue

4

Start / End Page

566 / 578

Location

United States

Related Subject Headings

  • Signal Transduction
  • Reverse Transcriptase Polymerase Chain Reaction
  • Osteoprotegerin
  • Osteoporosis
  • Osteogenesis
  • NF-kappa B
  • Mitogen-Activated Protein Kinase 14
  • Mice, Knockout
  • Mesenchymal Stem Cells
  • MAP Kinase Kinase Kinases
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Cong, Q., Jia, H., Biswas, S., Li, P., Qiu, S., Deng, Q., … Li, B. (2016). p38α MAPK Regulates Lineage Commitment and OPG Synthesis of Bone Marrow Stromal Cells to Prevent Bone Loss under Physiological and Pathological Conditions. Stem Cell Reports, 6(4), 566–578. https://doi.org/10.1016/j.stemcr.2016.02.001
Cong, Qian, Hao Jia, Soma Biswas, Ping Li, Shoutao Qiu, Qi Deng, Xizhi Guo, et al. “p38α MAPK Regulates Lineage Commitment and OPG Synthesis of Bone Marrow Stromal Cells to Prevent Bone Loss under Physiological and Pathological Conditions.Stem Cell Reports 6, no. 4 (April 12, 2016): 566–78. https://doi.org/10.1016/j.stemcr.2016.02.001.
Cong, Qian, et al. “p38α MAPK Regulates Lineage Commitment and OPG Synthesis of Bone Marrow Stromal Cells to Prevent Bone Loss under Physiological and Pathological Conditions.Stem Cell Reports, vol. 6, no. 4, Apr. 2016, pp. 566–78. Pubmed, doi:10.1016/j.stemcr.2016.02.001.
Cong Q, Jia H, Biswas S, Li P, Qiu S, Deng Q, Guo X, Ma G, Ling Chau JF, Wang Y, Zhang Z-L, Jiang X, Liu H, Li B. p38α MAPK Regulates Lineage Commitment and OPG Synthesis of Bone Marrow Stromal Cells to Prevent Bone Loss under Physiological and Pathological Conditions. Stem Cell Reports. 2016 Apr 12;6(4):566–578.
Journal cover image

Published In

Stem Cell Reports

DOI

EISSN

2213-6711

Publication Date

April 12, 2016

Volume

6

Issue

4

Start / End Page

566 / 578

Location

United States

Related Subject Headings

  • Signal Transduction
  • Reverse Transcriptase Polymerase Chain Reaction
  • Osteoprotegerin
  • Osteoporosis
  • Osteogenesis
  • NF-kappa B
  • Mitogen-Activated Protein Kinase 14
  • Mice, Knockout
  • Mesenchymal Stem Cells
  • MAP Kinase Kinase Kinases