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The Contributions of Maternal Sensitivity and Maternal Depressive Symptoms to Epigenetic Processes and Neuroendocrine Functioning.

Publication ,  Journal Article
Conradt, E; Hawes, K; Guerin, D; Armstrong, DA; Marsit, CJ; Tronick, E; Lester, BM
Published in: Child Dev
2016

This study tested whether maternal responsiveness may buffer the child to the effects of maternal depressive symptoms on DNA methylation of NR3C1, 11β-HSD2, and neuroendocrine functioning. DNA was derived from buccal epithelial cells and prestress cortisol was obtained from the saliva of 128 infants. Mothers with depressive symptoms who were more responsive and who engaged in more appropriate touch during face-to-face play had infants with less DNA methylation of NR3C1 and 11β-HSD2 compared to mothers with depressive symptoms who were also insensitive. The combination of exposure to maternal depressive symptoms and maternal sensitivity was related to the highest prestress cortisol levels, whereas exposure to maternal depressive symptoms and maternal insensitivity was related to the lowest prestress cortisol levels.

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Published In

Child Dev

DOI

EISSN

1467-8624

Publication Date

2016

Volume

87

Issue

1

Start / End Page

73 / 85

Location

United States

Related Subject Headings

  • Young Adult
  • Receptors, Glucocorticoid
  • Pregnancy Complications
  • Pregnancy
  • Maternal Behavior
  • Male
  • Infant
  • Hydrocortisone
  • Humans
  • Female
 

Citation

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ICMJE
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Conradt, E., Hawes, K., Guerin, D., Armstrong, D. A., Marsit, C. J., Tronick, E., & Lester, B. M. (2016). The Contributions of Maternal Sensitivity and Maternal Depressive Symptoms to Epigenetic Processes and Neuroendocrine Functioning. Child Dev, 87(1), 73–85. https://doi.org/10.1111/cdev.12483
Conradt, Elisabeth, Katheleen Hawes, Dylan Guerin, David A. Armstrong, Carmen J. Marsit, Edward Tronick, and Barry M. Lester. “The Contributions of Maternal Sensitivity and Maternal Depressive Symptoms to Epigenetic Processes and Neuroendocrine Functioning.Child Dev 87, no. 1 (2016): 73–85. https://doi.org/10.1111/cdev.12483.
Conradt E, Hawes K, Guerin D, Armstrong DA, Marsit CJ, Tronick E, et al. The Contributions of Maternal Sensitivity and Maternal Depressive Symptoms to Epigenetic Processes and Neuroendocrine Functioning. Child Dev. 2016;87(1):73–85.
Conradt, Elisabeth, et al. “The Contributions of Maternal Sensitivity and Maternal Depressive Symptoms to Epigenetic Processes and Neuroendocrine Functioning.Child Dev, vol. 87, no. 1, 2016, pp. 73–85. Pubmed, doi:10.1111/cdev.12483.
Conradt E, Hawes K, Guerin D, Armstrong DA, Marsit CJ, Tronick E, Lester BM. The Contributions of Maternal Sensitivity and Maternal Depressive Symptoms to Epigenetic Processes and Neuroendocrine Functioning. Child Dev. 2016;87(1):73–85.
Journal cover image

Published In

Child Dev

DOI

EISSN

1467-8624

Publication Date

2016

Volume

87

Issue

1

Start / End Page

73 / 85

Location

United States

Related Subject Headings

  • Young Adult
  • Receptors, Glucocorticoid
  • Pregnancy Complications
  • Pregnancy
  • Maternal Behavior
  • Male
  • Infant
  • Hydrocortisone
  • Humans
  • Female