The DEK protein--an abundant and ubiquitous constituent of mammalian chromatin.
Publication
, Journal Article
Waldmann, T; Scholten, I; Kappes, F; Hu, HG; Knippers, R
Published in: Gene
December 2004
The protein DEK is an abundant and ubiquitous chromatin protein in multicellular organisms (not in yeast). It is expressed in more than a million copies/nucleus of rapidly proliferating mammalian cells. DEK has two DNA binding modules of which one includes a SAP box, a sequence motif that DEK shares with a number of other chromatin proteins. DEK has no apparent affinity to specific DNA sequences, but preferentially binds to superhelical and cruciform DNA, and induces positive supercoils into closed circular DNA. The available evidence strongly suggests that DEK could function as an architectural protein in chromatin comparable to the better known classic architectural chromatin proteins, the high-mobility group or HMG proteins.
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Published In
Gene
DOI
EISSN
1879-0038
ISSN
0378-1119
Publication Date
December 2004
Volume
343
Issue
1
Start / End Page
1 / 9
Related Subject Headings
- Translocation, Genetic
- Poly-ADP-Ribose Binding Proteins
- Oncogenes
- Oncogene Proteins
- Nucleoproteins
- Leukemia, Myeloid, Acute
- Humans
- High Mobility Group Proteins
- Developmental Biology
- Chromosomes, Human, Pair 6
Citation
APA
Chicago
ICMJE
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NLM
Waldmann, T., Scholten, I., Kappes, F., Hu, H. G., & Knippers, R. (2004). The DEK protein--an abundant and ubiquitous constituent of mammalian chromatin. Gene, 343(1), 1–9. https://doi.org/10.1016/j.gene.2004.08.029
Waldmann, Tanja, Ingo Scholten, Ferdinand Kappes, Hong Gang Hu, and Rolf Knippers. “The DEK protein--an abundant and ubiquitous constituent of mammalian chromatin.” Gene 343, no. 1 (December 2004): 1–9. https://doi.org/10.1016/j.gene.2004.08.029.
Waldmann T, Scholten I, Kappes F, Hu HG, Knippers R. The DEK protein--an abundant and ubiquitous constituent of mammalian chromatin. Gene. 2004 Dec;343(1):1–9.
Waldmann, Tanja, et al. “The DEK protein--an abundant and ubiquitous constituent of mammalian chromatin.” Gene, vol. 343, no. 1, Dec. 2004, pp. 1–9. Epmc, doi:10.1016/j.gene.2004.08.029.
Waldmann T, Scholten I, Kappes F, Hu HG, Knippers R. The DEK protein--an abundant and ubiquitous constituent of mammalian chromatin. Gene. 2004 Dec;343(1):1–9.
Published In
Gene
DOI
EISSN
1879-0038
ISSN
0378-1119
Publication Date
December 2004
Volume
343
Issue
1
Start / End Page
1 / 9
Related Subject Headings
- Translocation, Genetic
- Poly-ADP-Ribose Binding Proteins
- Oncogenes
- Oncogene Proteins
- Nucleoproteins
- Leukemia, Myeloid, Acute
- Humans
- High Mobility Group Proteins
- Developmental Biology
- Chromosomes, Human, Pair 6