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The current landscape of immunotherapy for pediatric brain tumors.

Publication ,  Journal Article
Hwang, EI; Sayour, EJ; Flores, CT; Grant, G; Wechsler-Reya, R; Hoang-Minh, LB; Kieran, MW; Salcido, J; Prins, RM; Figg, JW; Platten, M ...
Published in: Nat Cancer
January 2022

Pediatric central nervous system tumors are the most common solid malignancies in childhood, and aggressive therapy often leads to long-term sequelae in survivors, making these tumors challenging to treat. Immunotherapy has revolutionized prospects for many cancer types in adults, but the intrinsic complexity of treating pediatric patients and the scarcity of clinical studies of children to inform effective approaches have hampered the development of effective immunotherapies in pediatric settings. Here, we review recent advances and ongoing challenges in pediatric brain cancer immunotherapy, as well as considerations for efficient clinical translation of efficacious immunotherapies into pediatric settings.

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Published In

Nat Cancer

DOI

EISSN

2662-1347

Publication Date

January 2022

Volume

3

Issue

1

Start / End Page

11 / 24

Location

England

Related Subject Headings

  • Survivors
  • Immunotherapy
  • Immunologic Factors
  • Humans
  • Child
  • Central Nervous System Neoplasms
  • Brain Neoplasms
  • 3211 Oncology and carcinogenesis
  • 3204 Immunology
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Hwang, E. I., Sayour, E. J., Flores, C. T., Grant, G., Wechsler-Reya, R., Hoang-Minh, L. B., … Pollack, I. F. (2022). The current landscape of immunotherapy for pediatric brain tumors. Nat Cancer, 3(1), 11–24. https://doi.org/10.1038/s43018-021-00319-0
Hwang, Eugene I., Elias J. Sayour, Catherine T. Flores, Gerald Grant, Robert Wechsler-Reya, Lan B. Hoang-Minh, Mark W. Kieran, et al. “The current landscape of immunotherapy for pediatric brain tumors.Nat Cancer 3, no. 1 (January 2022): 11–24. https://doi.org/10.1038/s43018-021-00319-0.
Hwang EI, Sayour EJ, Flores CT, Grant G, Wechsler-Reya R, Hoang-Minh LB, et al. The current landscape of immunotherapy for pediatric brain tumors. Nat Cancer. 2022 Jan;3(1):11–24.
Hwang, Eugene I., et al. “The current landscape of immunotherapy for pediatric brain tumors.Nat Cancer, vol. 3, no. 1, Jan. 2022, pp. 11–24. Pubmed, doi:10.1038/s43018-021-00319-0.
Hwang EI, Sayour EJ, Flores CT, Grant G, Wechsler-Reya R, Hoang-Minh LB, Kieran MW, Salcido J, Prins RM, Figg JW, Platten M, Candelario KM, Hale PG, Blatt JE, Governale LS, Okada H, Mitchell DA, Pollack IF. The current landscape of immunotherapy for pediatric brain tumors. Nat Cancer. 2022 Jan;3(1):11–24.

Published In

Nat Cancer

DOI

EISSN

2662-1347

Publication Date

January 2022

Volume

3

Issue

1

Start / End Page

11 / 24

Location

England

Related Subject Headings

  • Survivors
  • Immunotherapy
  • Immunologic Factors
  • Humans
  • Child
  • Central Nervous System Neoplasms
  • Brain Neoplasms
  • 3211 Oncology and carcinogenesis
  • 3204 Immunology