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Topical vancomycin for surgical prophylaxis in non-instrumented pediatric spinal surgeries.

Publication ,  Journal Article
Cannon, JGD; Ho, AL; Mohole, J; Pendharkar, AV; Sussman, ES; Cheshier, SH; Grant, GA
Published in: Childs Nerv Syst
January 2019

STUDY DESIGN: Retrospective cohort study. OBJECTIVE: To determine if topical vancomycin irrigation reduces the incidence of post-operative surgical site infections following pediatric spinal procedures. Surgical site infections (SSIs) following spinal procedures performed in pediatric patients represent a serious complication. Prophylactic use of topical vancomycin prior to closure has been shown to be effective in reducing incidence of SSIs in adult spinal procedures. Non-instrumented cases make up the majority of spinal procedures in pediatric patients, and the efficacy of prophylactic topical vancomycin in these procedures has not previously been reported. METHODS: This retrospective study reviewed all non-instrumented spinal procedures performed over a period from 05/2014-12/2016 for topical vancomycin use, surgical site infections, and clinical variables associated with SSI. Topical vancomycin was utilized as infection prophylaxis, and applied as a liquid solution within the wound prior to closure. RESULTS: Ninety-five consecutive, non-instrumented, pediatric spinal surgeries were completed between 01/2015 and 12/2016, of which the last 68 utilized topical vancomycin. There was a 11.1% SSI rate in the non-topical vancomycin cohort versus 0% in the topical vancomycin cohort (P = 0.005). The number needed to treat was 9. There were no significant differences in risk factors for SSI between cohorts. There were no complications associated topical vancomycin use. CONCLUSIONS: Routine topical vancomycin administration during closure of non-instrumented spinal procedures can be a safe and effective tool for reducing SSIs in the pediatric neurosurgical population.

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Published In

Childs Nerv Syst

DOI

EISSN

1433-0350

Publication Date

January 2019

Volume

35

Issue

1

Start / End Page

107 / 111

Location

Germany

Related Subject Headings

  • Vancomycin
  • Treatment Outcome
  • Surgical Wound Infection
  • Spine
  • Spinal Fusion
  • Retrospective Studies
  • Neurosurgical Procedures
  • Neurology & Neurosurgery
  • Male
  • Infant, Newborn
 

Citation

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Chicago
ICMJE
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Cannon, J. G. D., Ho, A. L., Mohole, J., Pendharkar, A. V., Sussman, E. S., Cheshier, S. H., & Grant, G. A. (2019). Topical vancomycin for surgical prophylaxis in non-instrumented pediatric spinal surgeries. Childs Nerv Syst, 35(1), 107–111. https://doi.org/10.1007/s00381-018-3881-z
Cannon, John G. D., Allen L. Ho, Jyodi Mohole, Arjun V. Pendharkar, Eric S. Sussman, Samuel H. Cheshier, and Gerald A. Grant. “Topical vancomycin for surgical prophylaxis in non-instrumented pediatric spinal surgeries.Childs Nerv Syst 35, no. 1 (January 2019): 107–11. https://doi.org/10.1007/s00381-018-3881-z.
Cannon JGD, Ho AL, Mohole J, Pendharkar AV, Sussman ES, Cheshier SH, et al. Topical vancomycin for surgical prophylaxis in non-instrumented pediatric spinal surgeries. Childs Nerv Syst. 2019 Jan;35(1):107–11.
Cannon, John G. D., et al. “Topical vancomycin for surgical prophylaxis in non-instrumented pediatric spinal surgeries.Childs Nerv Syst, vol. 35, no. 1, Jan. 2019, pp. 107–11. Pubmed, doi:10.1007/s00381-018-3881-z.
Cannon JGD, Ho AL, Mohole J, Pendharkar AV, Sussman ES, Cheshier SH, Grant GA. Topical vancomycin for surgical prophylaxis in non-instrumented pediatric spinal surgeries. Childs Nerv Syst. 2019 Jan;35(1):107–111.
Journal cover image

Published In

Childs Nerv Syst

DOI

EISSN

1433-0350

Publication Date

January 2019

Volume

35

Issue

1

Start / End Page

107 / 111

Location

Germany

Related Subject Headings

  • Vancomycin
  • Treatment Outcome
  • Surgical Wound Infection
  • Spine
  • Spinal Fusion
  • Retrospective Studies
  • Neurosurgical Procedures
  • Neurology & Neurosurgery
  • Male
  • Infant, Newborn