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A Virion-Based Combination Vaccine Protects against Influenza and SARS-CoV-2 Disease in Mice.

Publication ,  Journal Article
Chaparian, RR; Harding, AT; Hamele, CE; Riebe, K; Karlsson, A; Sempowski, GD; Heaton, NS; Heaton, BE
Published in: J Virol
August 10, 2022

Vaccines targeting SARS-CoV-2 have been shown to be highly effective; however, the breadth against emerging variants and the longevity of protection remains unclear. Postimmunization boosting has been shown to be beneficial for disease protection, and as new variants continue to emerge, periodic (and perhaps annual) vaccination will likely be recommended. New seasonal influenza virus vaccines currently need to be developed every year due to continual antigenic drift, an undertaking made possible by a robust global vaccine production and distribution infrastructure. To create a seasonal combination vaccine targeting both influenza viruses and SARS-CoV-2 that is also amenable to frequent reformulation, we have developed an influenza A virus (IAV) genetic platform that allows the incorporation of an immunogenic domain of the SARS-CoV-2 spike (S) protein onto IAV particles. Vaccination with this combination vaccine elicited neutralizing antibodies and provided protection from lethal challenge with both pathogens in mice. This approach may allow the leveraging of established influenza vaccine infrastructure to generate a cost-effective and scalable seasonal vaccine solution for both influenza and coronaviruses. IMPORTANCE The rapid emergence of SARS-CoV-2 variants since the onset of the pandemic has highlighted the need for both periodic vaccination "boosts" and a platform that can be rapidly reformulated to manufacture new vaccines. In this work, we report an approach that can utilize current influenza vaccine manufacturing infrastructure to generate combination vaccines capable of protecting from both influenza virus- and SARS-CoV-2-induced disease. The production of a combined influenza/SARS-CoV-2 vaccine may represent a practical solution to boost immunity to these important respiratory viruses without the increased cost and administration burden of multiple independent vaccines.

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Published In

J Virol

DOI

EISSN

1098-5514

Publication Date

August 10, 2022

Volume

96

Issue

15

Start / End Page

e0068922

Location

United States

Related Subject Headings

  • Virology
  • Virion
  • Vaccines, Combined
  • SARS-CoV-2
  • Orthomyxoviridae Infections
  • Mice
  • Influenza, Human
  • Influenza Vaccines
  • Influenza A virus
  • Humans
 

Citation

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Chicago
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Chaparian, R. R., Harding, A. T., Hamele, C. E., Riebe, K., Karlsson, A., Sempowski, G. D., … Heaton, B. E. (2022). A Virion-Based Combination Vaccine Protects against Influenza and SARS-CoV-2 Disease in Mice. J Virol, 96(15), e0068922. https://doi.org/10.1128/jvi.00689-22
Chaparian, Ryan R., Alfred T. Harding, Cait E. Hamele, Kristina Riebe, Amelia Karlsson, Gregory D. Sempowski, Nicholas S. Heaton, and Brook E. Heaton. “A Virion-Based Combination Vaccine Protects against Influenza and SARS-CoV-2 Disease in Mice.J Virol 96, no. 15 (August 10, 2022): e0068922. https://doi.org/10.1128/jvi.00689-22.
Chaparian RR, Harding AT, Hamele CE, Riebe K, Karlsson A, Sempowski GD, et al. A Virion-Based Combination Vaccine Protects against Influenza and SARS-CoV-2 Disease in Mice. J Virol. 2022 Aug 10;96(15):e0068922.
Chaparian, Ryan R., et al. “A Virion-Based Combination Vaccine Protects against Influenza and SARS-CoV-2 Disease in Mice.J Virol, vol. 96, no. 15, Aug. 2022, p. e0068922. Pubmed, doi:10.1128/jvi.00689-22.
Chaparian RR, Harding AT, Hamele CE, Riebe K, Karlsson A, Sempowski GD, Heaton NS, Heaton BE. A Virion-Based Combination Vaccine Protects against Influenza and SARS-CoV-2 Disease in Mice. J Virol. 2022 Aug 10;96(15):e0068922.

Published In

J Virol

DOI

EISSN

1098-5514

Publication Date

August 10, 2022

Volume

96

Issue

15

Start / End Page

e0068922

Location

United States

Related Subject Headings

  • Virology
  • Virion
  • Vaccines, Combined
  • SARS-CoV-2
  • Orthomyxoviridae Infections
  • Mice
  • Influenza, Human
  • Influenza Vaccines
  • Influenza A virus
  • Humans