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Could the Human Endogenous Retrovirus-Derived Syncytialization Inhibitor, Suppressyn, Limit Heterotypic Cell Fusion Events in the Decidua?

Publication ,  Journal Article
Sugimoto, J; Choi, S; Sheridan, MA; Koh, I; Kudo, Y; Schust, DJ
Published in: Int J Mol Sci
September 23, 2021

Proper placental development relies on tightly regulated trophoblast differentiation and interaction with maternal cells. Human endogenous retroviruses (HERVs) play an integral role in modulating cell fusion events in the trophoblast cells of the developing placenta. Syncytin-1 (ERVW-1) and its receptor, solute-linked carrier family A member 5 (SLC1A5/ASCT2), promote fusion of cytotrophoblast (CTB) cells to generate the multi-nucleated syncytiotrophoblast (STB) layer which is in direct contact with maternal blood. Another HERV-derived protein known as Suppressyn (ERVH48-1/SUPYN) is implicated in anti-fusogenic events as it shares the common receptor with ERVW-1. Here, we explore primary tissue and publicly available datasets to determine the distribution of ERVW-1, ERVH48-1 and SLC1A5 expression at the maternal-fetal interface. While SLC1A5 is broadly expressed in placental and decidual cell types, ERVW-1 and ERVH48-1 are confined to trophoblast cell types. ERVH48-1 displays higher expression levels in CTB and extravillous trophoblast, than in STB, while ERVW-1 is generally highest in STB. We have demonstrated through gene targeting studies that suppressyn has the ability to prevent ERVW-1-induced fusion events in co-culture models of trophoblast cell/maternal endometrial cell interactions. These findings suggest that differential HERV expression is vital to control fusion and anti-fusogenic events in the placenta and consequently, any imbalance or dysregulation in HERV expression may contribute to adverse pregnancy outcomes.

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Published In

Int J Mol Sci

DOI

EISSN

1422-0067

Publication Date

September 23, 2021

Volume

22

Issue

19

Location

Switzerland

Related Subject Headings

  • Trophoblasts
  • Pregnancy Proteins
  • Pregnancy
  • Placenta
  • Minor Histocompatibility Antigens
  • Humans
  • Gene Products, env
  • Female
  • Endogenous Retroviruses
  • Decidua
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Sugimoto, J., Choi, S., Sheridan, M. A., Koh, I., Kudo, Y., & Schust, D. J. (2021). Could the Human Endogenous Retrovirus-Derived Syncytialization Inhibitor, Suppressyn, Limit Heterotypic Cell Fusion Events in the Decidua? Int J Mol Sci, 22(19). https://doi.org/10.3390/ijms221910259
Sugimoto, Jun, Sehee Choi, Megan A. Sheridan, Iemasa Koh, Yoshiki Kudo, and Danny J. Schust. “Could the Human Endogenous Retrovirus-Derived Syncytialization Inhibitor, Suppressyn, Limit Heterotypic Cell Fusion Events in the Decidua?Int J Mol Sci 22, no. 19 (September 23, 2021). https://doi.org/10.3390/ijms221910259.
Sugimoto J, Choi S, Sheridan MA, Koh I, Kudo Y, Schust DJ. Could the Human Endogenous Retrovirus-Derived Syncytialization Inhibitor, Suppressyn, Limit Heterotypic Cell Fusion Events in the Decidua? Int J Mol Sci. 2021 Sep 23;22(19).
Sugimoto, Jun, et al. “Could the Human Endogenous Retrovirus-Derived Syncytialization Inhibitor, Suppressyn, Limit Heterotypic Cell Fusion Events in the Decidua?Int J Mol Sci, vol. 22, no. 19, Sept. 2021. Pubmed, doi:10.3390/ijms221910259.
Sugimoto J, Choi S, Sheridan MA, Koh I, Kudo Y, Schust DJ. Could the Human Endogenous Retrovirus-Derived Syncytialization Inhibitor, Suppressyn, Limit Heterotypic Cell Fusion Events in the Decidua? Int J Mol Sci. 2021 Sep 23;22(19).

Published In

Int J Mol Sci

DOI

EISSN

1422-0067

Publication Date

September 23, 2021

Volume

22

Issue

19

Location

Switzerland

Related Subject Headings

  • Trophoblasts
  • Pregnancy Proteins
  • Pregnancy
  • Placenta
  • Minor Histocompatibility Antigens
  • Humans
  • Gene Products, env
  • Female
  • Endogenous Retroviruses
  • Decidua