Skip to main content
Journal cover image

Effects of three long-acting reversible contraceptive methods on HIV target cells in the human uterine cervix and peripheral blood.

Publication ,  Journal Article
Li, L; Zhou, J; Wang, W; Huang, L; Tu, J; Baiamonte, L; Stark, M; Mills, M; Hope, TJ; Drobnis, EZ; Quayle, AJ; Schust, DJ
Published in: Reprod Biol Endocrinol
February 22, 2019

BACKGROUND: Hormonal contraceptives, particularly depot medroxyprogesterone acetate (DMPA), have been reported to be associated with substantially enhanced HIV acquisition; however, the biological mechanisms of this risk remain poorly understood. We aimed to investigate the effects of different hormonal contraceptives on the expression of the HIV co-receptors, CXCR4 and CCR5, on female endocervical and peripheral blood T cells. METHODS: A total of 59 HIV-negative women were enrolled, including 15 initiating DMPA, 28 initiating a levonorgestrel-releasing intrauterine device (LNG-IUD) and 16 initiating an etonogestrel (ETG)-delivering vaginal ring. Peripheral blood and endocervical cytobrush specimens were collected at enrollment and 3-4 weeks after contraception initiation to analyze the expression of CXCR4 and CCR5, on CD4+ and CD8+ T cells using flow cytometry. RESULTS: Administration of DMPA increased the percentages of CD4+ and CD8+ T cells expressing CCR5 in the endocervix but not in the peripheral blood. Administration of the LNG-IUD or the ETG vaginal ring did not affect the percentages of T lymphocytes expressing CXCR4 or CCR5 in the female cervix or peripheral blood. CONCLUSIONS: Increase in the percentage of endocervical T cells expressing CCR5 upon DMPA exposure provides a plausible biological explanation for the association between DMPA use and an elevated risk of HIV infection.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Reprod Biol Endocrinol

DOI

EISSN

1477-7827

Publication Date

February 22, 2019

Volume

17

Issue

1

Start / End Page

26

Location

England

Related Subject Headings

  • Young Adult
  • T-Lymphocytes
  • Receptors, CXCR4
  • Receptors, CCR5
  • Obstetrics & Reproductive Medicine
  • Medroxyprogesterone Acetate
  • Levonorgestrel
  • Humans
  • HIV Infections
  • HIV
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Li, L., Zhou, J., Wang, W., Huang, L., Tu, J., Baiamonte, L., … Schust, D. J. (2019). Effects of three long-acting reversible contraceptive methods on HIV target cells in the human uterine cervix and peripheral blood. Reprod Biol Endocrinol, 17(1), 26. https://doi.org/10.1186/s12958-019-0469-8
Li, Liping, Jie Zhou, Weijia Wang, Lina Huang, Jiaoqin Tu, Lyndsey Baiamonte, Moselle Stark, et al. “Effects of three long-acting reversible contraceptive methods on HIV target cells in the human uterine cervix and peripheral blood.Reprod Biol Endocrinol 17, no. 1 (February 22, 2019): 26. https://doi.org/10.1186/s12958-019-0469-8.
Li L, Zhou J, Wang W, Huang L, Tu J, Baiamonte L, et al. Effects of three long-acting reversible contraceptive methods on HIV target cells in the human uterine cervix and peripheral blood. Reprod Biol Endocrinol. 2019 Feb 22;17(1):26.
Li, Liping, et al. “Effects of three long-acting reversible contraceptive methods on HIV target cells in the human uterine cervix and peripheral blood.Reprod Biol Endocrinol, vol. 17, no. 1, Feb. 2019, p. 26. Pubmed, doi:10.1186/s12958-019-0469-8.
Li L, Zhou J, Wang W, Huang L, Tu J, Baiamonte L, Stark M, Mills M, Hope TJ, Drobnis EZ, Quayle AJ, Schust DJ. Effects of three long-acting reversible contraceptive methods on HIV target cells in the human uterine cervix and peripheral blood. Reprod Biol Endocrinol. 2019 Feb 22;17(1):26.
Journal cover image

Published In

Reprod Biol Endocrinol

DOI

EISSN

1477-7827

Publication Date

February 22, 2019

Volume

17

Issue

1

Start / End Page

26

Location

England

Related Subject Headings

  • Young Adult
  • T-Lymphocytes
  • Receptors, CXCR4
  • Receptors, CCR5
  • Obstetrics & Reproductive Medicine
  • Medroxyprogesterone Acetate
  • Levonorgestrel
  • Humans
  • HIV Infections
  • HIV