Skip to main content
Journal cover image

The prevalence of cervical regulatory T cells in HPV-related cervical intraepithelial neoplasia (CIN) correlates inversely with spontaneous regression of CIN.

Publication ,  Journal Article
Kojima, S; Kawana, K; Tomio, K; Yamashita, A; Taguchi, A; Miura, S; Adachi, K; Nagamatsu, T; Nagasaka, K; Matsumoto, Y; Arimoto, T; Oda, K ...
Published in: Am J Reprod Immunol
February 2013

PROBLEM: Local adaptive cervical regulatory T cells (Tregs) are the most likely direct suppressors of the immune eradication of cervical intraepithelial lesion (CIN). PD-1 expression on T cells induces Tregs. No studies have quantitatively analyzed the Tregs and PD-1+ cells residing in CIN lesions. METHOD OF STUDY: Cervical lymphocytes were collected using cytobrushes from CIN patients and analyzed by FACS analysis. Comparisons were made between populations of cervical Tregs and PD-1+ CD4+ T cells in CIN regressors and non-regressors. RESULTS: A median of 11% of cervical CD4+ T cells were Tregs, while a median of 30% were PD-1+ cells. The proportions of cervical CD4+ T cells that were Tregs and/or PD-1+ cells were significantly lower in CIN regressors when compared with non-regressors. CONCLUSIONS: The prevalence of cervical tolerogenic T cells correlates inversely with spontaneous regression of CIN. Cervical Tregs may play an important role in HPV-related neoplastic immunoevasion.

Duke Scholars

Published In

Am J Reprod Immunol

DOI

EISSN

1600-0897

Publication Date

February 2013

Volume

69

Issue

2

Start / End Page

134 / 141

Location

Denmark

Related Subject Headings

  • Uterine Cervical Neoplasms
  • Uterine Cervical Dysplasia
  • Papillomavirus Infections
  • Obstetrics & Reproductive Medicine
  • Neoplasm Regression, Spontaneous
  • Humans
  • Female
  • CD4-Positive T-Lymphocytes
  • 3215 Reproductive medicine
  • 3204 Immunology
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Kojima, S., Kawana, K., Tomio, K., Yamashita, A., Taguchi, A., Miura, S., … Kozuma, S. (2013). The prevalence of cervical regulatory T cells in HPV-related cervical intraepithelial neoplasia (CIN) correlates inversely with spontaneous regression of CIN. Am J Reprod Immunol, 69(2), 134–141. https://doi.org/10.1111/aji.12030
Kojima, Satoko, Kei Kawana, Kensuke Tomio, Aki Yamashita, Ayumi Taguchi, Shiho Miura, Katsuyuki Adachi, et al. “The prevalence of cervical regulatory T cells in HPV-related cervical intraepithelial neoplasia (CIN) correlates inversely with spontaneous regression of CIN.Am J Reprod Immunol 69, no. 2 (February 2013): 134–41. https://doi.org/10.1111/aji.12030.
Kojima S, Kawana K, Tomio K, Yamashita A, Taguchi A, Miura S, et al. The prevalence of cervical regulatory T cells in HPV-related cervical intraepithelial neoplasia (CIN) correlates inversely with spontaneous regression of CIN. Am J Reprod Immunol. 2013 Feb;69(2):134–41.
Kojima, Satoko, et al. “The prevalence of cervical regulatory T cells in HPV-related cervical intraepithelial neoplasia (CIN) correlates inversely with spontaneous regression of CIN.Am J Reprod Immunol, vol. 69, no. 2, Feb. 2013, pp. 134–41. Pubmed, doi:10.1111/aji.12030.
Kojima S, Kawana K, Tomio K, Yamashita A, Taguchi A, Miura S, Adachi K, Nagamatsu T, Nagasaka K, Matsumoto Y, Arimoto T, Oda K, Wada-Hiraike O, Yano T, Taketani Y, Fujii T, Schust DJ, Kozuma S. The prevalence of cervical regulatory T cells in HPV-related cervical intraepithelial neoplasia (CIN) correlates inversely with spontaneous regression of CIN. Am J Reprod Immunol. 2013 Feb;69(2):134–141.
Journal cover image

Published In

Am J Reprod Immunol

DOI

EISSN

1600-0897

Publication Date

February 2013

Volume

69

Issue

2

Start / End Page

134 / 141

Location

Denmark

Related Subject Headings

  • Uterine Cervical Neoplasms
  • Uterine Cervical Dysplasia
  • Papillomavirus Infections
  • Obstetrics & Reproductive Medicine
  • Neoplasm Regression, Spontaneous
  • Humans
  • Female
  • CD4-Positive T-Lymphocytes
  • 3215 Reproductive medicine
  • 3204 Immunology