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Gene expression profiling reveals progesterone-mediated cell cycle and immunoregulatory roles of Hoxa-10 in the preimplantation uterus.

Publication ,  Journal Article
Yao, MWM; Lim, H; Schust, DJ; Choe, SE; Farago, A; Ding, Y; Michaud, S; Church, GM; Maas, RL
Published in: Mol Endocrinol
April 2003

Human infertility and recurrent pregnancy loss caused by implantation defects are poorly understood. Hoxa-10-deficient female mice have severe infertility and recurrent pregnancy loss due to defective uterine implantation. Gene expression profiling experiments reveal that Hoxa-10 is an important regulator of two critical events in implantation: stromal cell proliferation and local immunosuppression. At the time of implantation, Hoxa-10 mediates the progesterone-stimulated proliferation of uterine stromal cells. Hoxa-10 mutants express a stromal cell proliferation defect that is accompanied by quantitative or spatial alterations in the expression of two cyclin-dependent kinase inhibitor genes, p57 and p15. Hoxa-10 deficiency also leads to a severe local immunological disturbance, characterized by a polyclonal proliferation of T cells, that occurs in place of the normal progesterone-mediated immunosuppression in the periimplantation uterus.

Duke Scholars

Published In

Mol Endocrinol

DOI

ISSN

0888-8809

Publication Date

April 2003

Volume

17

Issue

4

Start / End Page

610 / 627

Location

United States

Related Subject Headings

  • Uterus
  • Tumor Suppressor Proteins
  • T-Lymphocytes
  • Stromal Cells
  • Progesterone
  • Pregnancy
  • Ovariectomy
  • Nuclear Proteins
  • Molecular Sequence Data
  • Mice, Mutant Strains
 

Citation

APA
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MLA
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Yao, M. W. M., Lim, H., Schust, D. J., Choe, S. E., Farago, A., Ding, Y., … Maas, R. L. (2003). Gene expression profiling reveals progesterone-mediated cell cycle and immunoregulatory roles of Hoxa-10 in the preimplantation uterus. Mol Endocrinol, 17(4), 610–627. https://doi.org/10.1210/me.2002-0290
Yao, Mylene W. M., Hyunjung Lim, Daniel J. Schust, Sung E. Choe, Anna Farago, Yueyun Ding, Sebastien Michaud, George M. Church, and Richard L. Maas. “Gene expression profiling reveals progesterone-mediated cell cycle and immunoregulatory roles of Hoxa-10 in the preimplantation uterus.Mol Endocrinol 17, no. 4 (April 2003): 610–27. https://doi.org/10.1210/me.2002-0290.
Yao MWM, Lim H, Schust DJ, Choe SE, Farago A, Ding Y, et al. Gene expression profiling reveals progesterone-mediated cell cycle and immunoregulatory roles of Hoxa-10 in the preimplantation uterus. Mol Endocrinol. 2003 Apr;17(4):610–27.
Yao, Mylene W. M., et al. “Gene expression profiling reveals progesterone-mediated cell cycle and immunoregulatory roles of Hoxa-10 in the preimplantation uterus.Mol Endocrinol, vol. 17, no. 4, Apr. 2003, pp. 610–27. Pubmed, doi:10.1210/me.2002-0290.
Yao MWM, Lim H, Schust DJ, Choe SE, Farago A, Ding Y, Michaud S, Church GM, Maas RL. Gene expression profiling reveals progesterone-mediated cell cycle and immunoregulatory roles of Hoxa-10 in the preimplantation uterus. Mol Endocrinol. 2003 Apr;17(4):610–627.

Published In

Mol Endocrinol

DOI

ISSN

0888-8809

Publication Date

April 2003

Volume

17

Issue

4

Start / End Page

610 / 627

Location

United States

Related Subject Headings

  • Uterus
  • Tumor Suppressor Proteins
  • T-Lymphocytes
  • Stromal Cells
  • Progesterone
  • Pregnancy
  • Ovariectomy
  • Nuclear Proteins
  • Molecular Sequence Data
  • Mice, Mutant Strains