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Chlamydia trachomatis immune evasion via downregulation of MHC class I surface expression involves direct and indirect mechanisms.

Publication ,  Journal Article
Ibana, JA; Schust, DJ; Sugimoto, J; Nagamatsu, T; Greene, SJ; Quayle, AJ
Published in: Infect Dis Obstet Gynecol
2011

Genital C. trachomatis infections typically last for many months in women. This has been attributed to several strategies by which C. trachomatis evades immune detection, including well-described methods by which C. trachomatis decreases the cell surface expression of the antigen presenting molecules major histocompatibility complex (MHC) class I, MHC class II, and CD1d in infected genital epithelial cells. We have harnessed new methods that allow for separate evaluation of infected and uninfected cells within a mixed population of chlamydia-infected endocervical epithelial cells to demonstrate that MHC class I downregulation in the presence of C. trachomatis is mediated by direct and indirect (soluble) factors. Such indirect mechanisms may aid in priming surrounding cells for more rapid immune evasion upon pathogen entry and help promote unfettered spread of C. trachomatis genital infections.

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Published In

Infect Dis Obstet Gynecol

DOI

EISSN

1098-0997

Publication Date

2011

Volume

2011

Start / End Page

420905

Location

Egypt

Related Subject Headings

  • Obstetrics & Reproductive Medicine
  • Models, Biological
  • Microscopy, Fluorescence
  • Humans
  • Host-Pathogen Interactions
  • Histocompatibility Antigens Class I
  • Flow Cytometry
  • Female
  • Epithelial Cells
  • Down-Regulation
 

Citation

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Ibana, J. A., Schust, D. J., Sugimoto, J., Nagamatsu, T., Greene, S. J., & Quayle, A. J. (2011). Chlamydia trachomatis immune evasion via downregulation of MHC class I surface expression involves direct and indirect mechanisms. Infect Dis Obstet Gynecol, 2011, 420905. https://doi.org/10.1155/2011/420905
Ibana, Joyce A., Danny J. Schust, Jun Sugimoto, Takeshi Nagamatsu, Sheila J. Greene, and Alison J. Quayle. “Chlamydia trachomatis immune evasion via downregulation of MHC class I surface expression involves direct and indirect mechanisms.Infect Dis Obstet Gynecol 2011 (2011): 420905. https://doi.org/10.1155/2011/420905.
Ibana JA, Schust DJ, Sugimoto J, Nagamatsu T, Greene SJ, Quayle AJ. Chlamydia trachomatis immune evasion via downregulation of MHC class I surface expression involves direct and indirect mechanisms. Infect Dis Obstet Gynecol. 2011;2011:420905.
Ibana, Joyce A., et al. “Chlamydia trachomatis immune evasion via downregulation of MHC class I surface expression involves direct and indirect mechanisms.Infect Dis Obstet Gynecol, vol. 2011, 2011, p. 420905. Pubmed, doi:10.1155/2011/420905.
Ibana JA, Schust DJ, Sugimoto J, Nagamatsu T, Greene SJ, Quayle AJ. Chlamydia trachomatis immune evasion via downregulation of MHC class I surface expression involves direct and indirect mechanisms. Infect Dis Obstet Gynecol. 2011;2011:420905.
Journal cover image

Published In

Infect Dis Obstet Gynecol

DOI

EISSN

1098-0997

Publication Date

2011

Volume

2011

Start / End Page

420905

Location

Egypt

Related Subject Headings

  • Obstetrics & Reproductive Medicine
  • Models, Biological
  • Microscopy, Fluorescence
  • Humans
  • Host-Pathogen Interactions
  • Histocompatibility Antigens Class I
  • Flow Cytometry
  • Female
  • Epithelial Cells
  • Down-Regulation