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Oxygen metabolism in acute ischemic stroke.

Publication ,  Journal Article
Lin, W; Powers, WJ
Published in: J Cereb Blood Flow Metab
September 2018

Gaining insights into brain oxygen metabolism has been one of the key areas of research in neurosciences. Extensive efforts have been devoted to developing approaches capable of providing measures of brain oxygen metabolism not only under normal physiological conditions but, more importantly, in various pathophysiological conditions such as cerebral ischemia. In particular, quantitative measures of cerebral metabolic rate of oxygen using positron emission tomography (PET) have been shown to be capable of discerning brain tissue viability during ischemic insults. However, the complex logistics associated with oxygen-15 PET have substantially hampered its wide clinical applicability. In contrast, magnetic resonance imaging (MRI)-based approaches have provided quantitative measures of cerebral oxygen metabolism similar to that obtained using PET. Given the wide availability, MRI-based approaches may have broader clinical impacts, particularly in cerebral ischemia, when time is a critical factor in deciding treatment selection. In this article, we review the pathophysiological basis of altered cerebral hemodynamics and oxygen metabolism in cerebral ischemia, how quantitative measures of cerebral metabolism were obtained using the Kety-Schmidt approach, the physical concepts of non-invasive oxygen metabolism imaging approaches, and, finally, clinical applications of the discussed imaging approaches.

Duke Scholars

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Published In

J Cereb Blood Flow Metab

DOI

EISSN

1559-7016

Publication Date

September 2018

Volume

38

Issue

9

Start / End Page

1481 / 1499

Location

United States

Related Subject Headings

  • Stroke
  • Positron-Emission Tomography
  • Oxygen Consumption
  • Oxygen
  • Neurology & Neurosurgery
  • Neuroimaging
  • Magnetic Resonance Imaging
  • Humans
  • Hemodynamics
  • Cerebrovascular Circulation
 

Citation

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Lin, W., & Powers, W. J. (2018). Oxygen metabolism in acute ischemic stroke. J Cereb Blood Flow Metab, 38(9), 1481–1499. https://doi.org/10.1177/0271678X17722095
Lin, Weili, and William J. Powers. “Oxygen metabolism in acute ischemic stroke.J Cereb Blood Flow Metab 38, no. 9 (September 2018): 1481–99. https://doi.org/10.1177/0271678X17722095.
Lin W, Powers WJ. Oxygen metabolism in acute ischemic stroke. J Cereb Blood Flow Metab. 2018 Sep;38(9):1481–99.
Lin, Weili, and William J. Powers. “Oxygen metabolism in acute ischemic stroke.J Cereb Blood Flow Metab, vol. 38, no. 9, Sept. 2018, pp. 1481–99. Pubmed, doi:10.1177/0271678X17722095.
Lin W, Powers WJ. Oxygen metabolism in acute ischemic stroke. J Cereb Blood Flow Metab. 2018 Sep;38(9):1481–1499.
Journal cover image

Published In

J Cereb Blood Flow Metab

DOI

EISSN

1559-7016

Publication Date

September 2018

Volume

38

Issue

9

Start / End Page

1481 / 1499

Location

United States

Related Subject Headings

  • Stroke
  • Positron-Emission Tomography
  • Oxygen Consumption
  • Oxygen
  • Neurology & Neurosurgery
  • Neuroimaging
  • Magnetic Resonance Imaging
  • Humans
  • Hemodynamics
  • Cerebrovascular Circulation