Normal platelet mitochondrial complex I activity in Huntington's disease.
Publication
, Journal Article
Powers, WJ; Haas, RH; Le, T; Videen, TO; Hershey, T; McGee-Minnich, L; Perlmutter, JS
Published in: Neurobiol Dis
July 2007
Two small case series of platelet mitochondrial complex I activity assays in Huntington's Disease (HD) report discrepant results. We measured platelet complex I and complex I/III activity in 21 subjects with early gene-positive HD and 14 age-matched controls. The 21 participants with HD that we studied are greater than the total of 16 in the two previously published of platelet ETS activity in HD. Reductions > 10% were excluded with 80% confidence. A systemic defect in complex I activity is not present in early HD when striatal neuronal degeneration is already present.
Duke Scholars
Published In
Neurobiol Dis
DOI
ISSN
0969-9961
Publication Date
July 2007
Volume
27
Issue
1
Start / End Page
99 / 101
Location
United States
Related Subject Headings
- Neurology & Neurosurgery
- Mitochondria
- Middle Aged
- Male
- Huntington Disease
- Humans
- Female
- Enzyme Activation
- Electron Transport Complex III
- Electron Transport Complex I
Citation
APA
Chicago
ICMJE
MLA
NLM
Powers, W. J., Haas, R. H., Le, T., Videen, T. O., Hershey, T., McGee-Minnich, L., & Perlmutter, J. S. (2007). Normal platelet mitochondrial complex I activity in Huntington's disease. Neurobiol Dis, 27(1), 99–101. https://doi.org/10.1016/j.nbd.2007.04.008
Powers, William J., Richard H. Haas, Thuy Le, Tom O. Videen, Tamara Hershey, Lori McGee-Minnich, and Joel S. Perlmutter. “Normal platelet mitochondrial complex I activity in Huntington's disease.” Neurobiol Dis 27, no. 1 (July 2007): 99–101. https://doi.org/10.1016/j.nbd.2007.04.008.
Powers WJ, Haas RH, Le T, Videen TO, Hershey T, McGee-Minnich L, et al. Normal platelet mitochondrial complex I activity in Huntington's disease. Neurobiol Dis. 2007 Jul;27(1):99–101.
Powers, William J., et al. “Normal platelet mitochondrial complex I activity in Huntington's disease.” Neurobiol Dis, vol. 27, no. 1, July 2007, pp. 99–101. Pubmed, doi:10.1016/j.nbd.2007.04.008.
Powers WJ, Haas RH, Le T, Videen TO, Hershey T, McGee-Minnich L, Perlmutter JS. Normal platelet mitochondrial complex I activity in Huntington's disease. Neurobiol Dis. 2007 Jul;27(1):99–101.
Published In
Neurobiol Dis
DOI
ISSN
0969-9961
Publication Date
July 2007
Volume
27
Issue
1
Start / End Page
99 / 101
Location
United States
Related Subject Headings
- Neurology & Neurosurgery
- Mitochondria
- Middle Aged
- Male
- Huntington Disease
- Humans
- Female
- Enzyme Activation
- Electron Transport Complex III
- Electron Transport Complex I