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Validation of the dual radiotracer method for quantitative In-111 platelet scintigraphy.

Publication ,  Journal Article
Powers, WJ; Hopkins, KT; Welch, MJ
Published in: Thromb Res
April 15, 1984

We have developed a simple in vivo scintigraphic technique that permits accurate quantitative comparison of intravascular platelet deposition in blood vessels of similar size. Regional count information from scintigraphic images of In-111 platelets and Tc-99m red blood cells is used to determine the ratio of radioactivity in the thrombus relative to that in the blood. Multiplication of this ratio by the percent injected dose (%ID) of In-111 per ml of blood yields a quantity (%ID index) that is directly proportional to the %ID of In-111 platelets in the thrombus as measured in vitro (r = .879, p less than 0.005). This technique is well suited for quantitative studies of scintigraphically detectable platelet deposition in both animals and in man.

Duke Scholars

Published In

Thromb Res

DOI

ISSN

0049-3848

Publication Date

April 15, 1984

Volume

34

Issue

2

Start / End Page

135 / 145

Location

United States

Related Subject Headings

  • Time Factors
  • Thrombosis
  • Radionuclide Imaging
  • Radioisotopes
  • Rabbits
  • Platelet Count
  • Indium
  • Disease Models, Animal
  • Cardiovascular System & Hematology
  • Blood Platelets
 

Citation

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Powers, W. J., Hopkins, K. T., & Welch, M. J. (1984). Validation of the dual radiotracer method for quantitative In-111 platelet scintigraphy. Thromb Res, 34(2), 135–145. https://doi.org/10.1016/0049-3848(84)90070-7
Powers, W. J., K. T. Hopkins, and M. J. Welch. “Validation of the dual radiotracer method for quantitative In-111 platelet scintigraphy.Thromb Res 34, no. 2 (April 15, 1984): 135–45. https://doi.org/10.1016/0049-3848(84)90070-7.
Powers WJ, Hopkins KT, Welch MJ. Validation of the dual radiotracer method for quantitative In-111 platelet scintigraphy. Thromb Res. 1984 Apr 15;34(2):135–45.
Powers, W. J., et al. “Validation of the dual radiotracer method for quantitative In-111 platelet scintigraphy.Thromb Res, vol. 34, no. 2, Apr. 1984, pp. 135–45. Pubmed, doi:10.1016/0049-3848(84)90070-7.
Powers WJ, Hopkins KT, Welch MJ. Validation of the dual radiotracer method for quantitative In-111 platelet scintigraphy. Thromb Res. 1984 Apr 15;34(2):135–145.
Journal cover image

Published In

Thromb Res

DOI

ISSN

0049-3848

Publication Date

April 15, 1984

Volume

34

Issue

2

Start / End Page

135 / 145

Location

United States

Related Subject Headings

  • Time Factors
  • Thrombosis
  • Radionuclide Imaging
  • Radioisotopes
  • Rabbits
  • Platelet Count
  • Indium
  • Disease Models, Animal
  • Cardiovascular System & Hematology
  • Blood Platelets