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Blood-to-brain glucose transport and cerebral glucose metabolism are not reduced in poorly controlled type 1 diabetes.

Publication ,  Journal Article
Fanelli, CG; Dence, CS; Markham, J; Videen, TO; Paramore, DS; Cryer, PE; Powers, WJ
Published in: Diabetes
September 1998

To test the hypothesis that blood-to-brain glucose transport is reduced in poorly controlled type 1 diabetes, we studied seven patients with a mean (+/- SD) HbA1c level of 10.1 +/- 1.2% and nine nondiabetic subjects during hyperinsulinemic, mildly hypoglycemic (approximately 3.6 mmol/l, approximately 65 mg/dl) glucose clamps. Blood-to-brain glucose transport and cerebral glucose metabolism were calculated from rate constants derived from blood and brain time-activity curves--the latter determined by positron emission tomography (PET)--after intravenous injection of [1-(11)C]glucose using a model that includes a fourth rate constant to account for regional egress of 11C metabolites. Cerebral blood flow and cerebral blood volume were determined with intravenous H2(15)O and inhaled C(15)O, respectively, also by PET. At plateau plasma glucose concentrations of 3.6 +/- 0.0 and 3.7 +/- 0.1 mmol/l, rates of blood-to-brain glucose transport were similar in the two groups (23.7 +/- 2.2 and 21.6 +/- 2.9 micromol x 100 g(-1) x min(-1), P = 0.569, in the control subjects and the patients, respectively). There were also no differences in the rates of cerebral glucose metabolism (16.8 +/- 0.8 and 16.3 +/- 1.2 micromol x 100 g(-1) x min(-1), P = 0.693, respectively). Plasma epinephrine (1,380 +/- 340 vs. 450 +/- 170 pmol/l, P = 0.0440) and glucagon (26 +/- 5 vs. 12 +/- 1 pmol/l, P = 0.0300) responses to mild hypoglycemia were reduced in the patients with type 1 diabetes. We conclude that neither blood-to-brain glucose transport nor cerebral glucose metabolism is measurably reduced in people with poorly controlled type 1 diabetes.

Duke Scholars

Published In

Diabetes

DOI

ISSN

0012-1797

Publication Date

September 1998

Volume

47

Issue

9

Start / End Page

1444 / 1450

Location

United States

Related Subject Headings

  • Tomography, Emission-Computed
  • Reference Values
  • Pancreatic Polypeptide
  • Norepinephrine
  • Male
  • Insulin
  • Hydrocortisone
  • Humans
  • Human Growth Hormone
  • Heart Rate
 

Citation

APA
Chicago
ICMJE
MLA
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Fanelli, C. G., Dence, C. S., Markham, J., Videen, T. O., Paramore, D. S., Cryer, P. E., & Powers, W. J. (1998). Blood-to-brain glucose transport and cerebral glucose metabolism are not reduced in poorly controlled type 1 diabetes. Diabetes, 47(9), 1444–1450. https://doi.org/10.2337/diabetes.47.9.1444
Fanelli, C. G., C. S. Dence, J. Markham, T. O. Videen, D. S. Paramore, P. E. Cryer, and W. J. Powers. “Blood-to-brain glucose transport and cerebral glucose metabolism are not reduced in poorly controlled type 1 diabetes.Diabetes 47, no. 9 (September 1998): 1444–50. https://doi.org/10.2337/diabetes.47.9.1444.
Fanelli CG, Dence CS, Markham J, Videen TO, Paramore DS, Cryer PE, et al. Blood-to-brain glucose transport and cerebral glucose metabolism are not reduced in poorly controlled type 1 diabetes. Diabetes. 1998 Sep;47(9):1444–50.
Fanelli, C. G., et al. “Blood-to-brain glucose transport and cerebral glucose metabolism are not reduced in poorly controlled type 1 diabetes.Diabetes, vol. 47, no. 9, Sept. 1998, pp. 1444–50. Pubmed, doi:10.2337/diabetes.47.9.1444.
Fanelli CG, Dence CS, Markham J, Videen TO, Paramore DS, Cryer PE, Powers WJ. Blood-to-brain glucose transport and cerebral glucose metabolism are not reduced in poorly controlled type 1 diabetes. Diabetes. 1998 Sep;47(9):1444–1450.

Published In

Diabetes

DOI

ISSN

0012-1797

Publication Date

September 1998

Volume

47

Issue

9

Start / End Page

1444 / 1450

Location

United States

Related Subject Headings

  • Tomography, Emission-Computed
  • Reference Values
  • Pancreatic Polypeptide
  • Norepinephrine
  • Male
  • Insulin
  • Hydrocortisone
  • Humans
  • Human Growth Hormone
  • Heart Rate