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Hemodynamic effects of middle cerebral artery stenosis and occlusion

Publication ,  Conference
Derdeyn, CP; Powers, WJ; Grubb, RL
Published in: Rivista di Neuroradiologia
January 1, 1998

Middle cerebral artery (MCA) stenosis and occlusion may cause ischemic symptoms through both hemodynamic and embolic mechanisms. The purpose of this investigation was to determine the hemodynamic effects of these lesions. Ten patients with angiographically confirmed symptomatic occlusion (n = 5) or stenosis (n = 5) of the M1 segment of the MCA were studied with clinical evaluation, arteriography, and positron emission tomography (PET). Hemodynamic status was categorized by PET as: Stage 0, normal hemodynamics; Stage 1, autoregulatory vasodilatation (increased MTT); and Stage 2, increased OEF. Of five patients with MCA occlusion, three had autoregulatory vasodilatation (Stage 1) and 2 demonstrated increased OEF distal to the lesion (Stage 2). The MCA territory was supplied solely by pial collaterals in all five patients. Four of the five patients with focal MCA stenosis had normal hemodynamics (Stage 0). One patient was categorized as Stage 1. The frequency of hemodynamic compromise in patients with MCA occlusion is high. Pial collateralization is not a specific sign of increased OEF in patients with MCA occlusion.

Duke Scholars

Published In

Rivista di Neuroradiologia

DOI

ISSN

1120-9976

Publication Date

January 1, 1998

Volume

11

Issue

SUPPL. 2

Start / End Page

211 / 215

Related Subject Headings

  • Nuclear Medicine & Medical Imaging
  • 3209 Neurosciences
  • 3202 Clinical sciences
  • 1109 Neurosciences
  • 1103 Clinical Sciences
 

Citation

APA
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ICMJE
MLA
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Derdeyn, C. P., Powers, W. J., & Grubb, R. L. (1998). Hemodynamic effects of middle cerebral artery stenosis and occlusion. In Rivista di Neuroradiologia (Vol. 11, pp. 211–215). https://doi.org/10.1177/19714009980110s261
Derdeyn, C. P., W. J. Powers, and R. L. Grubb. “Hemodynamic effects of middle cerebral artery stenosis and occlusion.” In Rivista Di Neuroradiologia, 11:211–15, 1998. https://doi.org/10.1177/19714009980110s261.
Derdeyn CP, Powers WJ, Grubb RL. Hemodynamic effects of middle cerebral artery stenosis and occlusion. In: Rivista di Neuroradiologia. 1998. p. 211–5.
Derdeyn, C. P., et al. “Hemodynamic effects of middle cerebral artery stenosis and occlusion.” Rivista Di Neuroradiologia, vol. 11, no. SUPPL. 2, 1998, pp. 211–15. Scopus, doi:10.1177/19714009980110s261.
Derdeyn CP, Powers WJ, Grubb RL. Hemodynamic effects of middle cerebral artery stenosis and occlusion. Rivista di Neuroradiologia. 1998. p. 211–215.

Published In

Rivista di Neuroradiologia

DOI

ISSN

1120-9976

Publication Date

January 1, 1998

Volume

11

Issue

SUPPL. 2

Start / End Page

211 / 215

Related Subject Headings

  • Nuclear Medicine & Medical Imaging
  • 3209 Neurosciences
  • 3202 Clinical sciences
  • 1109 Neurosciences
  • 1103 Clinical Sciences