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Physical Activity in Stage III Colon Cancer: CALGB/SWOG 80702 (Alliance).

Publication ,  Journal Article
Brown, JC; Ma, C; Shi, Q; Fuchs, CS; Meyer, J; Niedzwiecki, D; Zemla, T; Couture, F; Kuebler, P; Kumar, P; Lewis, D; Tan, B; Krishnamurthi, S ...
Published in: J Clin Oncol
January 10, 2023

PURPOSE: To determine the specific types, durations, and intensities of recreational physical activity associated with the greatest improvements in disease-free survival (DFS) of patients with colon cancer. METHODS: We conducted a prospective cohort study nested within a randomized multicenter trial of stage III colon cancer that compared 3 versus 6 months of fluorouracil, leucovorin, and oxaliplatin with or without celecoxib. We measured recreational physical activity in the first 3 months of chemotherapy and again 6 months after completion of chemotherapy. The primary end point was DFS. RESULTS: During a median follow-up of 5.9 years, 457 of 1,696 patients experienced disease recurrence or death. For total recreational physical activity volume, the 3-year DFS was 76.5% with < 3.0 metabolic equivalent task hours per week (MET-h/wk) and 87.1% with ≥ 18.0 MET-h/wk (risk difference [RD], 10.6%; 95% CI, 4.7 to 19.4; P < .001). For light-intensity to moderate-intensity activities, the 3-year DFS was 65.7% with 0.0 h/wk and 87.1% with ≥ 1.5 h/wk (RD, 21.4%; 95% CI, 9.2 to 37.1; P < .001). For vigorous-intensity activity, the 3-year DFS was 76.0% with 0.0 h/wk and 86.0% with ≥ 1.0 h/wk (RD, 10.0%; 95% CI, 4.5 to 18.9; P < .001). For brisk walking, the 3-year DFS was 81.7% with < 1.0 h/wk and 88.4% with ≥ 3.0 h/wk (RD, 6.7%; 95% CI, 3.0 to 13.8; P < .001). For muscle strengthening activity, the 3-year DFS was 81.8% with 0.0 h/wk and 88.8% for ≥ 0.5 h/wk (RD, 7.0%; 95% CI, 3.1 to 14.2; P = .003). CONCLUSION: Among patients with stage III colon cancer enrolled in a trial of postoperative treatment, larger volumes of recreational physical activity, longer durations of light- to moderate-intensity aerobic physical activity, or any vigorous-intensity aerobic physical activity were associated with the greatest improvements in DFS.

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Published In

J Clin Oncol

DOI

EISSN

1527-7755

Publication Date

January 10, 2023

Volume

41

Issue

2

Start / End Page

243 / 254

Location

United States

Related Subject Headings

  • Prospective Studies
  • Oncology & Carcinogenesis
  • Neoplasm Staging
  • Neoplasm Recurrence, Local
  • Leucovorin
  • Humans
  • Fluorouracil
  • Exercise
  • Disease-Free Survival
  • Colonic Neoplasms
 

Citation

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Brown, J. C., Ma, C., Shi, Q., Fuchs, C. S., Meyer, J., Niedzwiecki, D., … Meyerhardt, J. A. (2023). Physical Activity in Stage III Colon Cancer: CALGB/SWOG 80702 (Alliance). J Clin Oncol, 41(2), 243–254. https://doi.org/10.1200/JCO.22.00171
Brown, Justin C., Chao Ma, Qian Shi, Charles S. Fuchs, Jeffrey Meyer, Donna Niedzwiecki, Tyler Zemla, et al. “Physical Activity in Stage III Colon Cancer: CALGB/SWOG 80702 (Alliance).J Clin Oncol 41, no. 2 (January 10, 2023): 243–54. https://doi.org/10.1200/JCO.22.00171.
Brown JC, Ma C, Shi Q, Fuchs CS, Meyer J, Niedzwiecki D, et al. Physical Activity in Stage III Colon Cancer: CALGB/SWOG 80702 (Alliance). J Clin Oncol. 2023 Jan 10;41(2):243–54.
Brown, Justin C., et al. “Physical Activity in Stage III Colon Cancer: CALGB/SWOG 80702 (Alliance).J Clin Oncol, vol. 41, no. 2, Jan. 2023, pp. 243–54. Pubmed, doi:10.1200/JCO.22.00171.
Brown JC, Ma C, Shi Q, Fuchs CS, Meyer J, Niedzwiecki D, Zemla T, Couture F, Kuebler P, Kumar P, Lewis D, Tan B, Krishnamurthi S, O’Reilly EM, Shields AF, Meyerhardt JA. Physical Activity in Stage III Colon Cancer: CALGB/SWOG 80702 (Alliance). J Clin Oncol. 2023 Jan 10;41(2):243–254.

Published In

J Clin Oncol

DOI

EISSN

1527-7755

Publication Date

January 10, 2023

Volume

41

Issue

2

Start / End Page

243 / 254

Location

United States

Related Subject Headings

  • Prospective Studies
  • Oncology & Carcinogenesis
  • Neoplasm Staging
  • Neoplasm Recurrence, Local
  • Leucovorin
  • Humans
  • Fluorouracil
  • Exercise
  • Disease-Free Survival
  • Colonic Neoplasms