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Right ventricular outflow tract reconstruction using a Goretex membrane monocusp valve in infant animals.

Publication ,  Journal Article
Izutani, H; Gundry, SR; Vricella, LA; Xu, H; Bailey, LL
Published in: ASAIO J
2000

We examined the feasibility of using a polytetrafluoroethylene membrane (goretex) valve and transannular patch (TAP) for right ventricular outflow tract (RVOT) reconstruction in growing animal models. Eleven infant goats (Group A) and 12 infant sheep (Group B) underwent RVOT reconstruction under cardiopulmonary bypass. In Group A, a monocusp valve was constructed of goretex, and the RVOT was roofed over utilizing a TAP of bovine pericardium. In Group B, both a monocusp valve and a TAP were constructed of goretex. Animals were sacrificed at 6 or 12 postoperative months. Two goats in Group A died at 9 days and 4 months postoperatively due to RVOT obstruction caused by thrombus formation. Seven goats in Group A and 11 in Group B showed no pressure gradient across the valve. All animals in Group B revealed mild to moderate valvular insufficiency, but no ventricular deterioration. In contrast to the bovine pericardium, which showed a prominent fibroinflammatory reaction with calcified areas causing TAP shrinkage and RVOT stenosis, there was minimal calcification and inflammatory reaction directed against the goretex valve and TAP. We conclude that goretex can be used as a material from which to create both a monocusp valve and TAP for long-term RVOT reconstruction.

Duke Scholars

Published In

ASAIO J

DOI

ISSN

1058-2916

Publication Date

2000

Volume

46

Issue

5

Start / End Page

553 / 555

Location

United States

Related Subject Headings

  • Polytetrafluoroethylene
  • Heart Ventricles
  • Goats
  • Cattle
  • Biomedical Engineering
  • Animals
  • 0903 Biomedical Engineering
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Izutani, H., Gundry, S. R., Vricella, L. A., Xu, H., & Bailey, L. L. (2000). Right ventricular outflow tract reconstruction using a Goretex membrane monocusp valve in infant animals. ASAIO J, 46(5), 553–555. https://doi.org/10.1097/00002480-200009000-00008
Izutani, H., S. R. Gundry, L. A. Vricella, H. Xu, and L. L. Bailey. “Right ventricular outflow tract reconstruction using a Goretex membrane monocusp valve in infant animals.ASAIO J 46, no. 5 (2000): 553–55. https://doi.org/10.1097/00002480-200009000-00008.
Izutani H, Gundry SR, Vricella LA, Xu H, Bailey LL. Right ventricular outflow tract reconstruction using a Goretex membrane monocusp valve in infant animals. ASAIO J. 2000;46(5):553–5.
Izutani, H., et al. “Right ventricular outflow tract reconstruction using a Goretex membrane monocusp valve in infant animals.ASAIO J, vol. 46, no. 5, 2000, pp. 553–55. Pubmed, doi:10.1097/00002480-200009000-00008.
Izutani H, Gundry SR, Vricella LA, Xu H, Bailey LL. Right ventricular outflow tract reconstruction using a Goretex membrane monocusp valve in infant animals. ASAIO J. 2000;46(5):553–555.

Published In

ASAIO J

DOI

ISSN

1058-2916

Publication Date

2000

Volume

46

Issue

5

Start / End Page

553 / 555

Location

United States

Related Subject Headings

  • Polytetrafluoroethylene
  • Heart Ventricles
  • Goats
  • Cattle
  • Biomedical Engineering
  • Animals
  • 0903 Biomedical Engineering