Therapeutic targets for neuroblastomas.
Neuroblastoma (NB) is the most common and deadly solid tumor in children. Despite recent improvements, the long-term outlook for high-risk NB is still < 50%. Further, there is considerable short- and long-term toxicity. More effective, less toxic therapy is needed, and the development of targeted therapies offers great promise.Relevant literature was reviewed to identify current and future therapeutic targets that are critical to malignant transformation and progression of NB. The potential or actual NB therapeutic targets are classified into four categories: i) genes activated by amplification, mutation, translocation or autocrine overexpression; ii) genes inactivated by deletion, mutation or epigenetic silencing; iii) membrane-associated genes expressed on most NBs but few other tissues; or iv) common target genes relevant to NB as well as other tumors.Therapeutic approaches have been developed to some of these targets, but many remain untargeted at the present time. It is unlikely that single targeted agents will be sufficient for long-term cure, at least for high-risk NBs. The challenge will be how to integrate targeted agents with each other and with conventional therapy to enhance their efficacy, while simultaneously reducing systemic toxicity.
Duke Scholars
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Related Subject Headings
- Oncology & Carcinogenesis
- Neuroblastoma
- Nervous System Neoplasms
- Mutation
- Humans
- Gene Silencing
- Epigenesis, Genetic
- Animals
- 1115 Pharmacology and Pharmaceutical Sciences
- 0801 Artificial Intelligence and Image Processing
Citation
Published In
DOI
EISSN
ISSN
Publication Date
Volume
Issue
Start / End Page
Related Subject Headings
- Oncology & Carcinogenesis
- Neuroblastoma
- Nervous System Neoplasms
- Mutation
- Humans
- Gene Silencing
- Epigenesis, Genetic
- Animals
- 1115 Pharmacology and Pharmaceutical Sciences
- 0801 Artificial Intelligence and Image Processing