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Effects of Sexual Network Connectivity and Antimicrobial Drug Use on Antimicrobial Resistance in Neisseria gonorrhoeae.

Publication ,  Journal Article
Kenyon, CR; Schwartz, IS
Published in: Emerg Infect Dis
July 2018

Contemporary strategies to curtail the emergence of antimicrobial resistance in Neisseria gonorrhoeae include screening for and treating asymptomatic infections in high-prevalence populations in whom antimicrobial drug-resistant infections have typically emerged. We argue that antimicrobial resistance in these groups is driven by a combination of dense sexual network connectivity and antimicrobial drug exposure (for example, through screen-and-treat strategies for asymptomatic N. gonorrhoeae infection). Sexual network connectivity sustains a high-equilibrium prevalence of N. gonorrhoeae and increases likelihood of reinfection, whereas antimicrobial drug exposure results in selection pressure for reinfecting N. gonorrhoeae strains to acquire antimicrobial resistance genes from commensal pharyngeal or rectal flora. We propose study designs to test this hypothesis.

Duke Scholars

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Published In

Emerg Infect Dis

DOI

EISSN

1080-6059

Publication Date

July 2018

Volume

24

Issue

7

Start / End Page

1195 / 1203

Location

United States

Related Subject Headings

  • Sexually Transmitted Diseases, Bacterial
  • Sexual Behavior
  • Prevalence
  • Neisseria gonorrhoeae
  • Microbiology
  • Male
  • Humans
  • Gonorrhea
  • Female
  • Drug Resistance, Bacterial
 

Citation

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Kenyon, C. R., & Schwartz, I. S. (2018). Effects of Sexual Network Connectivity and Antimicrobial Drug Use on Antimicrobial Resistance in Neisseria gonorrhoeae. Emerg Infect Dis, 24(7), 1195–1203. https://doi.org/10.3201/eid2407.172104
Kenyon, Chris R., and Ilan S. Schwartz. “Effects of Sexual Network Connectivity and Antimicrobial Drug Use on Antimicrobial Resistance in Neisseria gonorrhoeae.Emerg Infect Dis 24, no. 7 (July 2018): 1195–1203. https://doi.org/10.3201/eid2407.172104.
Kenyon, Chris R., and Ilan S. Schwartz. “Effects of Sexual Network Connectivity and Antimicrobial Drug Use on Antimicrobial Resistance in Neisseria gonorrhoeae.Emerg Infect Dis, vol. 24, no. 7, July 2018, pp. 1195–203. Pubmed, doi:10.3201/eid2407.172104.

Published In

Emerg Infect Dis

DOI

EISSN

1080-6059

Publication Date

July 2018

Volume

24

Issue

7

Start / End Page

1195 / 1203

Location

United States

Related Subject Headings

  • Sexually Transmitted Diseases, Bacterial
  • Sexual Behavior
  • Prevalence
  • Neisseria gonorrhoeae
  • Microbiology
  • Male
  • Humans
  • Gonorrhea
  • Female
  • Drug Resistance, Bacterial