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The association between language-based task-functional magnetic resonance imaging hemodynamics and baseline GABA+ and glutamate-glutamine measured in pre-supplementary motor area: A pilot study in an aging model.

Publication ,  Journal Article
Krishnamurthy, LC; Paredes Spir, I; Rocha, NO; Soher, BJ; Auerbach, EJ; Crosson, BA; Krishnamurthy, V
Published in: Front Psychiatry
2022

Aging is a natural phenomenon that elicits slow and progressive cerebrovascular and neurophysiological changes that eventually lead to cognitive decline. The objective of this pilot study is to examine the association of GABA+ and glutamate-glutamine (Glx) complex with language-based blood oxygen level dependent (BOLD) hemodynamics in an aging model. More specifically, using standard BOLD we will first attempt to validate whether previously reported findings for BOLD amplitude and resting neurochemical relationships hold in an aging model. Secondly, we will investigate how our recently established neurosensitized task-BOLD energetics relate to resting GABA+ and Glx, especially accounting for titration of task difficulty. To support the above endeavors, we optimize the baseline fitting for edited magnetic resonance spectroscopy (MRS) difference spectra to sensitize GABA+ and Glx concentrations to aging-related differences. We identify a spline-knot spacing of 0.6ppm to yield the optimal aging-related differences in GABA+ and Glx. The optimized MRS values were then graduated to relate to task-BOLD hemodynamics. Our results did not replicate previous findings that relate task-BOLD amplitude and resting GABA+ and Glx. However, we did identify neurochemistry relationships with the vascularly-driven dispersion component of the hemodynamic response function, specifically in older participants. In terms of neuro-sensitized BOLD energetics and the underlying role of GABA+ and Glx, our data suggests that the task demands are supported by both neurometabolites depending on the difficulty of the task stimuli. Another novelty is that we developed task-based functional parcellation of pre-SMA using both groups. In sum, we are the first to demonstrate that multimodal task-fMRI and MRS studies are beneficial to improve our understanding of the aging brain physiology, and to set the platform to better inform approaches for clinical care in aging-related neurovascular diseases. We also urge future studies to replicate our findings in a larger population incorporating a lifespan framework.

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Published In

Front Psychiatry

DOI

ISSN

1664-0640

Publication Date

2022

Volume

13

Start / End Page

904845

Location

Switzerland

Related Subject Headings

  • 3202 Clinical sciences
  • 1701 Psychology
  • 1117 Public Health and Health Services
  • 1103 Clinical Sciences
 

Citation

APA
Chicago
ICMJE
MLA
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Krishnamurthy, L. C., Paredes Spir, I., Rocha, N. O., Soher, B. J., Auerbach, E. J., Crosson, B. A., & Krishnamurthy, V. (2022). The association between language-based task-functional magnetic resonance imaging hemodynamics and baseline GABA+ and glutamate-glutamine measured in pre-supplementary motor area: A pilot study in an aging model. Front Psychiatry, 13, 904845. https://doi.org/10.3389/fpsyt.2022.904845
Krishnamurthy, Lisa C., Isabella Paredes Spir, Natalie O. Rocha, Brian J. Soher, Edward J. Auerbach, Bruce A. Crosson, and Venkatagiri Krishnamurthy. “The association between language-based task-functional magnetic resonance imaging hemodynamics and baseline GABA+ and glutamate-glutamine measured in pre-supplementary motor area: A pilot study in an aging model.Front Psychiatry 13 (2022): 904845. https://doi.org/10.3389/fpsyt.2022.904845.

Published In

Front Psychiatry

DOI

ISSN

1664-0640

Publication Date

2022

Volume

13

Start / End Page

904845

Location

Switzerland

Related Subject Headings

  • 3202 Clinical sciences
  • 1701 Psychology
  • 1117 Public Health and Health Services
  • 1103 Clinical Sciences