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Transfusion Medicine and Hemostasis: Clinical and Laboratory Aspects

LDL pheresis

Publication ,  Chapter
Shaz, BH
June 8, 2009

This chapter gives an account of the treatment procedure known as LDL pheresis. It involves the removal of apo-B-containing low density lipoprotein (LDL) and lipoprotein(a) [Lp(a)]. LDL pheresis is indicated in the treatment of familial hypercholesterolemia (FH), which is an autosomal dominant disorder associated with mutations of hepatocyte apolipoprotein-B (apo-B) receptors resulting in decreased LDL removal by the liver. FH homozygotes have cholesterol in the range of 700-1200 mg/dl and heterozygotes have 350-500 mg/dl, resulting in premature coronary heart diseases. FDA approved indications for LDL pheresis are patients with hypercholesterolemia who are unresponsive to dietary and pharmacologic management or unable to tolerate medications. A single procedure reduces LDL cholesterol levels by 50-60% and treatment intervals every 2-3 weeks maintain an approximate 50% reduction in cholesterol levels. LDL pheresis is performed indefinitely to maintain target lipoprotein levels. Long-term outcome studies have demonstrated a significant reduction in the number of cardiovascular events. The use of angiotensin converting enzyme (ACE) inhibitors is contraindicated in patients undergoing LDL apheresis.

Duke Scholars

DOI

ISBN

9780123744326

Publication Date

June 8, 2009

Start / End Page

411 / 411
 

Citation

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Shaz, B. H. (2009). LDL pheresis. In Transfusion Medicine and Hemostasis: Clinical and Laboratory Aspects (pp. 411–411). https://doi.org/10.1016/B978-0-12-374432-6.00073-7
Shaz, B. H. “LDL pheresis.” In Transfusion Medicine and Hemostasis: Clinical and Laboratory Aspects, 411–411, 2009. https://doi.org/10.1016/B978-0-12-374432-6.00073-7.
Shaz BH. LDL pheresis. In: Transfusion Medicine and Hemostasis: Clinical and Laboratory Aspects. 2009. p. 411–411.
Shaz, B. H. “LDL pheresis.” Transfusion Medicine and Hemostasis: Clinical and Laboratory Aspects, 2009, pp. 411–411. Scopus, doi:10.1016/B978-0-12-374432-6.00073-7.
Shaz BH. LDL pheresis. Transfusion Medicine and Hemostasis: Clinical and Laboratory Aspects. 2009. p. 411–411.
Journal cover image

DOI

ISBN

9780123744326

Publication Date

June 8, 2009

Start / End Page

411 / 411