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Colorectal Neoplasia in CDH1 Pathogenic Variant Carriers: A Multicenter Analysis.

Publication ,  Journal Article
Stanich, PP; Elgindi, D; Stoffel, E; Koeppe, E; Bansal, A; Stetson, R; Collins, DL; Clark, DF; Karloski, E; Dudley, B; Brand, RE; Hall, MJ ...
Published in: Am J Gastroenterol
November 1, 2022

INTRODUCTION: Germline variants in CDH1 are associated with elevated risks of diffuse gastric cancer and lobular breast cancer. It is uncertain whether there is an increased risk of colorectal neoplasia. METHODS: This was a retrospective analysis of colonoscopy outcomes in patients with germline CDH1 pathogenic/likely pathogenic variants. RESULTS: Eighty-five patients were included with a mean age of 46.9 years. Initial colonoscopy found adenomatous polyps in 30 patients (35.3%), including advanced adenomas in 9 (10.6%). No colorectal cancers were identified on index or subsequent colonoscopies (when available). DISCUSSION: CDH1 carriers have colorectal neoplasia identified at similar rates as in the general population. Despite potential difficulties after gastrectomy, colorectal cancer screening remains important in this population.

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Published In

Am J Gastroenterol

DOI

EISSN

1572-0241

Publication Date

November 1, 2022

Volume

117

Issue

11

Start / End Page

1877 / 1879

Location

United States

Related Subject Headings

  • Retrospective Studies
  • Middle Aged
  • Humans
  • Germ-Line Mutation
  • Gastroenterology & Hepatology
  • Female
  • Colorectal Neoplasms
  • Colonoscopy
  • Cadherins
  • Breast Neoplasms
 

Citation

APA
Chicago
ICMJE
MLA
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Stanich, P. P., Elgindi, D., Stoffel, E., Koeppe, E., Bansal, A., Stetson, R., … Kupfer, S. S. (2022). Colorectal Neoplasia in CDH1 Pathogenic Variant Carriers: A Multicenter Analysis. Am J Gastroenterol, 117(11), 1877–1879. https://doi.org/10.14309/ajg.0000000000001996
Stanich, Peter P., Dareen Elgindi, Elena Stoffel, Erika Koeppe, Ajay Bansal, Rachel Stetson, Debra L. Collins, et al. “Colorectal Neoplasia in CDH1 Pathogenic Variant Carriers: A Multicenter Analysis.Am J Gastroenterol 117, no. 11 (November 1, 2022): 1877–79. https://doi.org/10.14309/ajg.0000000000001996.
Stanich PP, Elgindi D, Stoffel E, Koeppe E, Bansal A, Stetson R, et al. Colorectal Neoplasia in CDH1 Pathogenic Variant Carriers: A Multicenter Analysis. Am J Gastroenterol. 2022 Nov 1;117(11):1877–9.
Stanich, Peter P., et al. “Colorectal Neoplasia in CDH1 Pathogenic Variant Carriers: A Multicenter Analysis.Am J Gastroenterol, vol. 117, no. 11, Nov. 2022, pp. 1877–79. Pubmed, doi:10.14309/ajg.0000000000001996.
Stanich PP, Elgindi D, Stoffel E, Koeppe E, Bansal A, Stetson R, Collins DL, Clark DF, Karloski E, Dudley B, Brand RE, Hall MJ, Chertock Y, Sullivan BA, Muller C, Hinton A, Katona BW, Kupfer SS. Colorectal Neoplasia in CDH1 Pathogenic Variant Carriers: A Multicenter Analysis. Am J Gastroenterol. 2022 Nov 1;117(11):1877–1879.

Published In

Am J Gastroenterol

DOI

EISSN

1572-0241

Publication Date

November 1, 2022

Volume

117

Issue

11

Start / End Page

1877 / 1879

Location

United States

Related Subject Headings

  • Retrospective Studies
  • Middle Aged
  • Humans
  • Germ-Line Mutation
  • Gastroenterology & Hepatology
  • Female
  • Colorectal Neoplasms
  • Colonoscopy
  • Cadherins
  • Breast Neoplasms