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Racial differences in the association of body mass index and ovarian cancer risk in the OCWAA Consortium.

Publication ,  Journal Article
Ochs-Balcom, HM; Johnson, C; Guertin, KA; Qin, B; Beeghly-Fadiel, A; Camacho, F; Bethea, TN; Dempsey, LF; Rosenow, W; Joslin, CE; Myers, E ...
Published in: Br J Cancer
November 2022

BACKGROUND: Obesity disproportionately affects African American (AA) women and has been shown to increase ovarian cancer risk, with some suggestions that the association may differ by race. METHODS: We evaluated body mass index (BMI) and invasive epithelial ovarian cancer (EOC) risk in a pooled study of case-control and nested case-control studies including AA and White women. We evaluated both young adult and recent BMI (within the last 5 years). Associations were estimated using multi-level and multinomial logistic regression models. RESULTS: The sample included 1078 AA cases, 2582 AA controls, 3240 White cases and 9851 White controls. We observed a higher risk for the non-high-grade serous (NHGS) histotypes for AA women with obesity (ORBMI 30+= 1.62, 95% CI: 1.16, 2.26) and White women with obesity (ORBMI 30+= 1.20, 95% CI: 1.02, 2.42) compared to non-obese. Obesity was associated with higher NHGS risk in White women who never used HT (ORBMI 30+= 1.40, 95% CI: 1.08, 1.82). Higher NHGS ovarian cancer risk was observed for AA women who ever used HT (ORBMI 30+= 2.66, 95% CI: 1.15, 6.13), while in White women, there was an inverse association between recent BMI and risk of EOC and HGS in ever-HT users (EOC ORBMI 30+= 0.81, 95% CI: 0.69, 0.95, HGS ORBMI 30+= 0.73, 95% CI: 0.61, 0.88). CONCLUSION: Obesity contributes to NHGS EOC risk in AA and White women, but risk across racial groups studied differs by HT use and histotype.

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Published In

Br J Cancer

DOI

EISSN

1532-1827

Publication Date

November 2022

Volume

127

Issue

11

Start / End Page

1983 / 1990

Location

England

Related Subject Headings

  • Young Adult
  • Risk Factors
  • Race Factors
  • Ovarian Neoplasms
  • Oncology & Carcinogenesis
  • Obesity
  • Humans
  • Female
  • Case-Control Studies
  • Carcinoma, Ovarian Epithelial
 

Citation

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Ochs-Balcom, H. M., Johnson, C., Guertin, K. A., Qin, B., Beeghly-Fadiel, A., Camacho, F., … Bandera, E. V. (2022). Racial differences in the association of body mass index and ovarian cancer risk in the OCWAA Consortium. Br J Cancer, 127(11), 1983–1990. https://doi.org/10.1038/s41416-022-01981-6
Ochs-Balcom, Heather M., Courtney Johnson, Kristin A. Guertin, Bo Qin, Alicia Beeghly-Fadiel, Fabian Camacho, Traci N. Bethea, et al. “Racial differences in the association of body mass index and ovarian cancer risk in the OCWAA Consortium.Br J Cancer 127, no. 11 (November 2022): 1983–90. https://doi.org/10.1038/s41416-022-01981-6.
Ochs-Balcom HM, Johnson C, Guertin KA, Qin B, Beeghly-Fadiel A, Camacho F, et al. Racial differences in the association of body mass index and ovarian cancer risk in the OCWAA Consortium. Br J Cancer. 2022 Nov;127(11):1983–90.
Ochs-Balcom, Heather M., et al. “Racial differences in the association of body mass index and ovarian cancer risk in the OCWAA Consortium.Br J Cancer, vol. 127, no. 11, Nov. 2022, pp. 1983–90. Pubmed, doi:10.1038/s41416-022-01981-6.
Ochs-Balcom HM, Johnson C, Guertin KA, Qin B, Beeghly-Fadiel A, Camacho F, Bethea TN, Dempsey LF, Rosenow W, Joslin CE, Myers E, Moorman PG, Harris HR, Peres LC, Wendy Setiawan V, Wu AH, Rosenberg L, Schildkraut JM, Bandera EV. Racial differences in the association of body mass index and ovarian cancer risk in the OCWAA Consortium. Br J Cancer. 2022 Nov;127(11):1983–1990.

Published In

Br J Cancer

DOI

EISSN

1532-1827

Publication Date

November 2022

Volume

127

Issue

11

Start / End Page

1983 / 1990

Location

England

Related Subject Headings

  • Young Adult
  • Risk Factors
  • Race Factors
  • Ovarian Neoplasms
  • Oncology & Carcinogenesis
  • Obesity
  • Humans
  • Female
  • Case-Control Studies
  • Carcinoma, Ovarian Epithelial