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Decreased outflow facility and Schlemm's canal defects in a mouse model of glaucoma.

Publication ,  Journal Article
Mavlyutov, TA; Kuhn, MS; Bilal, SE; De Ieso, ML; Chauhan, AK; Stamer, WD; McDowell, CM
Published in: Exp Eye Res
December 2022

Previously we identified B6.EDA+/+ mice as a novel mouse model that presents with elevated IOP and trabecular meshwork damage. Here, we expand on our previous findings by measuring aqueous humor outflow facility and analyzing the integrity of the inner wall of Schlemm's canal. As expected, intraocular pressure (IOP) was increased, and outflow facility was decreased compared to C57BL/6J controls. B6.EDA+/+ mice had significantly increased expression of the adherens junction protein, VE-cadherin by the inner wall endothelium of Schlemm's canal. These data suggest that in addition to trabecular meshwork damage, there are changes in Schlemm's canal in B6.EDA+/+ mice that lead to aqueous outflow dysfunction and ocular hypertension.

Duke Scholars

Published In

Exp Eye Res

DOI

EISSN

1096-0007

Publication Date

December 2022

Volume

225

Start / End Page

109249

Location

England

Related Subject Headings

  • Trabecular Meshwork
  • Sclera
  • Ophthalmology & Optometry
  • Mice, Inbred C57BL
  • Mice
  • Intraocular Pressure
  • Glaucoma
  • Disease Models, Animal
  • Aqueous Humor
  • Animals
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Mavlyutov, T. A., Kuhn, M. S., Bilal, S. E., De Ieso, M. L., Chauhan, A. K., Stamer, W. D., & McDowell, C. M. (2022). Decreased outflow facility and Schlemm's canal defects in a mouse model of glaucoma. Exp Eye Res, 225, 109249. https://doi.org/10.1016/j.exer.2022.109249
Mavlyutov, Timur A., Megan S. Kuhn, Samer E. Bilal, Michael L. De Ieso, Anil K. Chauhan, W Daniel Stamer, and Colleen M. McDowell. “Decreased outflow facility and Schlemm's canal defects in a mouse model of glaucoma.Exp Eye Res 225 (December 2022): 109249. https://doi.org/10.1016/j.exer.2022.109249.
Mavlyutov TA, Kuhn MS, Bilal SE, De Ieso ML, Chauhan AK, Stamer WD, et al. Decreased outflow facility and Schlemm's canal defects in a mouse model of glaucoma. Exp Eye Res. 2022 Dec;225:109249.
Mavlyutov, Timur A., et al. “Decreased outflow facility and Schlemm's canal defects in a mouse model of glaucoma.Exp Eye Res, vol. 225, Dec. 2022, p. 109249. Pubmed, doi:10.1016/j.exer.2022.109249.
Mavlyutov TA, Kuhn MS, Bilal SE, De Ieso ML, Chauhan AK, Stamer WD, McDowell CM. Decreased outflow facility and Schlemm's canal defects in a mouse model of glaucoma. Exp Eye Res. 2022 Dec;225:109249.
Journal cover image

Published In

Exp Eye Res

DOI

EISSN

1096-0007

Publication Date

December 2022

Volume

225

Start / End Page

109249

Location

England

Related Subject Headings

  • Trabecular Meshwork
  • Sclera
  • Ophthalmology & Optometry
  • Mice, Inbred C57BL
  • Mice
  • Intraocular Pressure
  • Glaucoma
  • Disease Models, Animal
  • Aqueous Humor
  • Animals