Skip to main content

Dysfunction of the stress response in individuals with persistent post-concussion symptoms: a scoping review

Publication ,  Journal Article
Farrell, G; Wang, S; Chapple, C; Kennedy, E; Gisselman, AS; Sampath, K; Cook, C; Tumilty, S
Published in: Physical Therapy Reviews
January 1, 2022

Background: Preliminary evidence suggests that individuals with persistent post-concussion symptoms (PPCS) have a dysfunctional stress response, consisting of the autonomic nervous system (ANS) and hypothalamic pituitary adrenal-axis (HPA-axis). Objectives: This review aims to explore the extent of evidence for dysfunction of the stress response in individuals with PPCS by individually mapping the literature surrounding quantifiable changes of the (1) ANS and (2) HPA-axis using non-invasive and clinical tools, and highlighting any (3) knowledge gaps. Methods: Nine electronic databases and grey literature were searched on the 1st of June 2021 and 4th of October 2021. Studies were included if their population was classified with PPCS, and their study stated at least one quantifiable marker of the ANS or HPA-axis using non-invasive and clinical tools. Relevant studies were screened, and data extracted. Results: A total of 37 articles were included in this scoping review. The majority of studies assessed quantifiable markers of the ANS (n = 34), in comparison to the HPA-axis (n = 2), and ANS and HPA-axis (n = 1). The most common quantifiable markers of the ANS included heart rate (n = 20), blood pressure (n = 16), and heart rate variability (n = 10). Cortisol was the only included quantifiable marker of the HPA-axis (n = 2). Conclusions: Most of the evidence in this review supports quantifiable dysfunction of the ANS in those with PPCS. Further research is required investigating quantifiable dysfunction of the HPA-axis, and subsequently ANS and HPA-axis in unison, in those with PPCS.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Physical Therapy Reviews

DOI

EISSN

1743-288X

ISSN

1083-3196

Publication Date

January 1, 2022

Volume

27

Issue

5

Start / End Page

384 / 405

Related Subject Headings

  • 4207 Sports science and exercise
  • 4201 Allied health and rehabilitation science
  • 1106 Human Movement and Sports Sciences
  • 1103 Clinical Sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Farrell, G., Wang, S., Chapple, C., Kennedy, E., Gisselman, A. S., Sampath, K., … Tumilty, S. (2022). Dysfunction of the stress response in individuals with persistent post-concussion symptoms: a scoping review. Physical Therapy Reviews, 27(5), 384–405. https://doi.org/10.1080/10833196.2022.2096195
Farrell, G., S. Wang, C. Chapple, E. Kennedy, A. S. Gisselman, K. Sampath, C. Cook, and S. Tumilty. “Dysfunction of the stress response in individuals with persistent post-concussion symptoms: a scoping review.” Physical Therapy Reviews 27, no. 5 (January 1, 2022): 384–405. https://doi.org/10.1080/10833196.2022.2096195.
Farrell G, Wang S, Chapple C, Kennedy E, Gisselman AS, Sampath K, et al. Dysfunction of the stress response in individuals with persistent post-concussion symptoms: a scoping review. Physical Therapy Reviews. 2022 Jan 1;27(5):384–405.
Farrell, G., et al. “Dysfunction of the stress response in individuals with persistent post-concussion symptoms: a scoping review.” Physical Therapy Reviews, vol. 27, no. 5, Jan. 2022, pp. 384–405. Scopus, doi:10.1080/10833196.2022.2096195.
Farrell G, Wang S, Chapple C, Kennedy E, Gisselman AS, Sampath K, Cook C, Tumilty S. Dysfunction of the stress response in individuals with persistent post-concussion symptoms: a scoping review. Physical Therapy Reviews. 2022 Jan 1;27(5):384–405.

Published In

Physical Therapy Reviews

DOI

EISSN

1743-288X

ISSN

1083-3196

Publication Date

January 1, 2022

Volume

27

Issue

5

Start / End Page

384 / 405

Related Subject Headings

  • 4207 Sports science and exercise
  • 4201 Allied health and rehabilitation science
  • 1106 Human Movement and Sports Sciences
  • 1103 Clinical Sciences