Effect of a 17alpha-(3-hydroxypropyl)-17beta-acetyl substituent pattern on the glucocorticoid and progestin receptor binding of 11beta-arylestra-4,9-dien-3-ones.
Publication
, Journal Article
Cook, CE; Raje, P; Lee, DY; Kepler, JA
Published in: Org Lett
April 5, 2001
[structure: see text]. Replacing the 17alpha-acetoxy substituent in an antiprogestational 17beta-acetyl-11beta-arylestra-4,9-dien-3-one by 3-hydroxypropyl significantly diminished glucocorticoid receptor binding with little effect on progestin receptor binding.
Duke Scholars
Published In
Org Lett
ISSN
1523-7060
Publication Date
April 5, 2001
Volume
3
Issue
7
Start / End Page
1013 / 1016
Location
United States
Related Subject Headings
- Receptors, Progesterone
- Receptors, Glucocorticoid
- Rabbits
- Progestins
- Organic Chemistry
- Molecular Structure
- Ligands
- Humans
- Glucocorticoids
- Estrenes
Citation
APA
Chicago
ICMJE
MLA
NLM
Cook, C. E., Raje, P., Lee, D. Y., & Kepler, J. A. (2001). Effect of a 17alpha-(3-hydroxypropyl)-17beta-acetyl substituent pattern on the glucocorticoid and progestin receptor binding of 11beta-arylestra-4,9-dien-3-ones. Org Lett, 3(7), 1013–1016.
Cook, C. E., P. Raje, D. Y. Lee, and J. A. Kepler. “Effect of a 17alpha-(3-hydroxypropyl)-17beta-acetyl substituent pattern on the glucocorticoid and progestin receptor binding of 11beta-arylestra-4,9-dien-3-ones.” Org Lett 3, no. 7 (April 5, 2001): 1013–16.
Cook CE, Raje P, Lee DY, Kepler JA. Effect of a 17alpha-(3-hydroxypropyl)-17beta-acetyl substituent pattern on the glucocorticoid and progestin receptor binding of 11beta-arylestra-4,9-dien-3-ones. Org Lett. 2001 Apr 5;3(7):1013–6.
Cook, C. E., et al. “Effect of a 17alpha-(3-hydroxypropyl)-17beta-acetyl substituent pattern on the glucocorticoid and progestin receptor binding of 11beta-arylestra-4,9-dien-3-ones.” Org Lett, vol. 3, no. 7, Apr. 2001, pp. 1013–16.
Cook CE, Raje P, Lee DY, Kepler JA. Effect of a 17alpha-(3-hydroxypropyl)-17beta-acetyl substituent pattern on the glucocorticoid and progestin receptor binding of 11beta-arylestra-4,9-dien-3-ones. Org Lett. 2001 Apr 5;3(7):1013–1016.
Published In
Org Lett
ISSN
1523-7060
Publication Date
April 5, 2001
Volume
3
Issue
7
Start / End Page
1013 / 1016
Location
United States
Related Subject Headings
- Receptors, Progesterone
- Receptors, Glucocorticoid
- Rabbits
- Progestins
- Organic Chemistry
- Molecular Structure
- Ligands
- Humans
- Glucocorticoids
- Estrenes