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7alpha,11beta-Dimethyl-19-nortestosterone: a potent and selective androgen response modulator with prostate-sparing properties.

Publication ,  Journal Article
Cook, CE; Kepler, JA
Published in: Bioorg Med Chem Lett
February 15, 2005

7alpha,11beta-Dimethyl-19-nortestosterone, made by 1,6-methyl addition to 17beta-acetoxy-11beta-methylestra-4,6-dien-3-one, was a highly potent and selective androgen response modulator, with enhanced androgen receptor binding, androgenic activity and anabolic:androgenic ratio over its two monomethyl homologs.

Duke Scholars

Published In

Bioorg Med Chem Lett

DOI

ISSN

0960-894X

Publication Date

February 15, 2005

Volume

15

Issue

4

Start / End Page

1213 / 1216

Location

England

Related Subject Headings

  • Testosterone Congeners
  • Structure-Activity Relationship
  • Receptors, Androgen
  • Rats
  • Prostate
  • Organ Size
  • Nandrolone
  • Medicinal & Biomolecular Chemistry
  • Male
  • Female
 

Citation

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Cook, C. E., & Kepler, J. A. (2005). 7alpha,11beta-Dimethyl-19-nortestosterone: a potent and selective androgen response modulator with prostate-sparing properties. Bioorg Med Chem Lett, 15(4), 1213–1216. https://doi.org/10.1016/j.bmcl.2004.11.076
Cook, C Edgar, and John A. Kepler. “7alpha,11beta-Dimethyl-19-nortestosterone: a potent and selective androgen response modulator with prostate-sparing properties.Bioorg Med Chem Lett 15, no. 4 (February 15, 2005): 1213–16. https://doi.org/10.1016/j.bmcl.2004.11.076.
Cook, C. Edgar, and John A. Kepler. “7alpha,11beta-Dimethyl-19-nortestosterone: a potent and selective androgen response modulator with prostate-sparing properties.Bioorg Med Chem Lett, vol. 15, no. 4, Feb. 2005, pp. 1213–16. Pubmed, doi:10.1016/j.bmcl.2004.11.076.
Journal cover image

Published In

Bioorg Med Chem Lett

DOI

ISSN

0960-894X

Publication Date

February 15, 2005

Volume

15

Issue

4

Start / End Page

1213 / 1216

Location

England

Related Subject Headings

  • Testosterone Congeners
  • Structure-Activity Relationship
  • Receptors, Androgen
  • Rats
  • Prostate
  • Organ Size
  • Nandrolone
  • Medicinal & Biomolecular Chemistry
  • Male
  • Female