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Contributions of CD8 T cells to the pathogenesis of mouse adenovirus type 1 respiratory infection.

Publication ,  Journal Article
Molloy, CT; Andonian, JS; Seltzer, HM; Procario, MC; Watson, ME; Weinberg, JB
Published in: Virology
July 2017

CD8 T cells are key components of the immune response to viruses, but their roles in the pathogenesis of adenovirus respiratory infection have not been characterized. We used mouse adenovirus type 1 (MAV-1) to define CD8 T cell contributions to the pathogenesis of adenovirus respiratory infection. CD8 T cell deficiency in β2m-/- mice had no effect on peak viral replication in lungs, but clearance of virus was delayed in β2m-/- mice. Virus-induced weight loss and increases in bronchoalveolar lavage fluid total protein, IFN-γ, TNF-α, IL-10, CCL2, and CCL5 concentrations were less in β2m-/- mice than in controls. CD8 T cell depletion had similar effects on virus clearance, weight loss, and inflammation. Deficiency of IFN-γ or perforin had no effect on viral replication or inflammation, but perforin-deficient mice were partially protected from weight loss. CD8 T cells promote MAV-1-induced pulmonary inflammation via a mechanism that is independent of direct antiviral effects.

Duke Scholars

Published In

Virology

DOI

EISSN

1096-0341

Publication Date

July 2017

Volume

507

Start / End Page

64 / 74

Location

United States

Related Subject Headings

  • Virus Replication
  • Virology
  • Rodent Diseases
  • Perforin
  • Mice, Inbred C57BL
  • Mice
  • Mastadenovirus
  • Male
  • Lung
  • Interleukin-10
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Molloy, C. T., Andonian, J. S., Seltzer, H. M., Procario, M. C., Watson, M. E., & Weinberg, J. B. (2017). Contributions of CD8 T cells to the pathogenesis of mouse adenovirus type 1 respiratory infection. Virology, 507, 64–74. https://doi.org/10.1016/j.virol.2017.04.005
Molloy, Caitlyn T., Jennifer S. Andonian, Harrison M. Seltzer, Megan C. Procario, Michael E. Watson, and Jason B. Weinberg. “Contributions of CD8 T cells to the pathogenesis of mouse adenovirus type 1 respiratory infection.Virology 507 (July 2017): 64–74. https://doi.org/10.1016/j.virol.2017.04.005.
Molloy CT, Andonian JS, Seltzer HM, Procario MC, Watson ME, Weinberg JB. Contributions of CD8 T cells to the pathogenesis of mouse adenovirus type 1 respiratory infection. Virology. 2017 Jul;507:64–74.
Molloy, Caitlyn T., et al. “Contributions of CD8 T cells to the pathogenesis of mouse adenovirus type 1 respiratory infection.Virology, vol. 507, July 2017, pp. 64–74. Pubmed, doi:10.1016/j.virol.2017.04.005.
Molloy CT, Andonian JS, Seltzer HM, Procario MC, Watson ME, Weinberg JB. Contributions of CD8 T cells to the pathogenesis of mouse adenovirus type 1 respiratory infection. Virology. 2017 Jul;507:64–74.
Journal cover image

Published In

Virology

DOI

EISSN

1096-0341

Publication Date

July 2017

Volume

507

Start / End Page

64 / 74

Location

United States

Related Subject Headings

  • Virus Replication
  • Virology
  • Rodent Diseases
  • Perforin
  • Mice, Inbred C57BL
  • Mice
  • Mastadenovirus
  • Male
  • Lung
  • Interleukin-10