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The immunoproteasome and viral infection: a complex regulator of inflammation.

Publication ,  Journal Article
McCarthy, MK; Weinberg, JB
Published in: Front Microbiol
2015

During viral infection, proper regulation of immune responses is necessary to ensure successful viral clearance with minimal host tissue damage. Proteasomes play a crucial role in the generation of antigenic peptides for presentation on MHC class I molecules, and thus activation of CD8 T cells, as well as activation of the NF-κB pathway. A specialized type of proteasome called the immunoproteasome is constitutively expressed in hematopoietic cells and induced in non-immune cells during viral infection by interferon signaling. The immunoproteasome regulates CD8 T cell responses to many viral epitopes during infection. Accumulating evidence suggests that the immunoproteasome may also contribute to regulation of proinflammatory cytokine production, activation of the NF-κB pathway, and management of oxidative stress. Many viruses have mechanisms of interfering with immunoproteasome function, including prevention of transcriptional upregulation of immunoproteasome components as well as direct interaction of viral proteins with immunoproteasome subunits. A better understanding of the role of the immunoproteasome in different cell types, tissues, and hosts has the potential to improve vaccine design and facilitate the development of effective treatment strategies for viral infections.

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Published In

Front Microbiol

DOI

ISSN

1664-302X

Publication Date

2015

Volume

6

Start / End Page

21

Location

Switzerland

Related Subject Headings

  • 3207 Medical microbiology
  • 3107 Microbiology
  • 0605 Microbiology
  • 0503 Soil Sciences
  • 0502 Environmental Science and Management
 

Citation

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McCarthy, M. K., & Weinberg, J. B. (2015). The immunoproteasome and viral infection: a complex regulator of inflammation. Front Microbiol, 6, 21. https://doi.org/10.3389/fmicb.2015.00021
McCarthy, Mary K., and Jason B. Weinberg. “The immunoproteasome and viral infection: a complex regulator of inflammation.Front Microbiol 6 (2015): 21. https://doi.org/10.3389/fmicb.2015.00021.
McCarthy MK, Weinberg JB. The immunoproteasome and viral infection: a complex regulator of inflammation. Front Microbiol. 2015;6:21.
McCarthy, Mary K., and Jason B. Weinberg. “The immunoproteasome and viral infection: a complex regulator of inflammation.Front Microbiol, vol. 6, 2015, p. 21. Pubmed, doi:10.3389/fmicb.2015.00021.
McCarthy MK, Weinberg JB. The immunoproteasome and viral infection: a complex regulator of inflammation. Front Microbiol. 2015;6:21.

Published In

Front Microbiol

DOI

ISSN

1664-302X

Publication Date

2015

Volume

6

Start / End Page

21

Location

Switzerland

Related Subject Headings

  • 3207 Medical microbiology
  • 3107 Microbiology
  • 0605 Microbiology
  • 0503 Soil Sciences
  • 0502 Environmental Science and Management