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Acute respiratory infection with mouse adenovirus type 1.

Publication ,  Journal Article
Weinberg, JB; Stempfle, GS; Wilkinson, JE; Younger, JG; Spindler, KR
Published in: Virology
September 30, 2005

Studies of the pathogenesis of adenovirus respiratory disease are limited by the strict species-specificity of the adenoviruses. Following intranasal inoculation of adult C57BL/6 mice with mouse adenovirus type 1 (MAV-1), we detected MAV-1 early region 3 (E3) and hexon gene expression in the lungs at 7 days post-infection (dpi). We detected MAV-1 E3 protein in the respiratory epithelium at 7 dpi. We did not detect viral mRNA or protein at 14 dpi, but MAV-1 DNA was detected by PCR at 21 dpi. Chemokine transcript levels increased between 7 and 14 dpi in the lungs of infected mice. MAV-1 infection induced a patchy cellular infiltrate in lungs at 7 and 14 dpi. This is the first report demonstrating the presence of MAV-1 in the respiratory epithelium of infected mice and describing chemokine responses in the lung induced by MAV-1 respiratory infection. MAV-1 infection of mice has the potential to serve as a model for inflammatory changes seen in human adenovirus respiratory disease.

Duke Scholars

Published In

Virology

DOI

ISSN

0042-6822

Publication Date

September 30, 2005

Volume

340

Issue

2

Start / End Page

245 / 254

Location

United States

Related Subject Headings

  • Virology
  • Respiratory Tract Infections
  • RNA, Viral
  • Polymerase Chain Reaction
  • Mice, Inbred C57BL
  • Mice
  • Mastadenovirus
  • Lung
  • Inflammation
  • Disease Models, Animal
 

Citation

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Weinberg, J. B., Stempfle, G. S., Wilkinson, J. E., Younger, J. G., & Spindler, K. R. (2005). Acute respiratory infection with mouse adenovirus type 1. Virology, 340(2), 245–254. https://doi.org/10.1016/j.virol.2005.06.021
Weinberg, Jason B., Gregory S. Stempfle, John E. Wilkinson, John G. Younger, and Katherine R. Spindler. “Acute respiratory infection with mouse adenovirus type 1.Virology 340, no. 2 (September 30, 2005): 245–54. https://doi.org/10.1016/j.virol.2005.06.021.
Weinberg JB, Stempfle GS, Wilkinson JE, Younger JG, Spindler KR. Acute respiratory infection with mouse adenovirus type 1. Virology. 2005 Sep 30;340(2):245–54.
Weinberg, Jason B., et al. “Acute respiratory infection with mouse adenovirus type 1.Virology, vol. 340, no. 2, Sept. 2005, pp. 245–54. Pubmed, doi:10.1016/j.virol.2005.06.021.
Weinberg JB, Stempfle GS, Wilkinson JE, Younger JG, Spindler KR. Acute respiratory infection with mouse adenovirus type 1. Virology. 2005 Sep 30;340(2):245–254.
Journal cover image

Published In

Virology

DOI

ISSN

0042-6822

Publication Date

September 30, 2005

Volume

340

Issue

2

Start / End Page

245 / 254

Location

United States

Related Subject Headings

  • Virology
  • Respiratory Tract Infections
  • RNA, Viral
  • Polymerase Chain Reaction
  • Mice, Inbred C57BL
  • Mice
  • Mastadenovirus
  • Lung
  • Inflammation
  • Disease Models, Animal