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Relation of Cannabis Use to Elevated Atherosclerotic Cardiovascular Disease Risk Score.

Publication ,  Journal Article
Skipina, TM; Patel, N; Upadhya, B; Soliman, EZ
Published in: Am J Cardiol
February 15, 2022

We hypothesized that cannabis use is associated with cardiovascular disease (CVD) risk factors. This could explain the reported link between cannabis and cardiovascular events including stroke and myocardial infarction. This analysis included 7,159 participants (age 37.8 ± 12.4 years, 48.6% men, and 61.5% Caucasian) from the National Health and Nutrition Examination Survey years 2011 to 2018. Cannabis use was defined by self-report. Participants with a history of stroke or myocardial infarction were excluded. Composite CVD risk was assessed using the American College of Cardiology/American Heart Association 10-year atherosclerotic cardiovascular risk (ASCVD) score. Participants were classified based on their ASCVD risk levels as low (<5.0%), borderline (5.0% to 7.4%), intermediate (7.5% to 19.9%), and high (≥20.0%). Multinomial logistic regression was used to examine the association between cannabis use and ASCVD risk category using low-risk ASCVD category as the reference level. About 63.9% (n = 4,573) of participants had ever used cannabis. Ever cannabis use was associated with 60% increased odds of high-risk ASCVD score (odds ratio [OR] 95% confidence interval [CI] 1.60 [1.04 to 2.45], p = 0.03). We also observed a dose-response relation between increased use of cannabis and a higher risk of ASCVD. Those reporting ≥2 uses per month had 79% increased odds of high-risk ASCVD score (OR [95% CI] 1.79 [1.10 to 2.92], p = 0.02) and those reporting ≥1 use per day had 87% increased odds of high-risk ASCVD score (OR [95% CI] 1.87 [1.16 to 3.01], p <0.001]. In conclusion, cannabis use is associated with elevated CVD risk. Individuals using cannabis should be screened for CVD risk, and appropriate risk reduction strategies should be implemented.

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Published In

Am J Cardiol

DOI

EISSN

1879-1913

Publication Date

February 15, 2022

Volume

165

Start / End Page

46 / 50

Location

United States

Related Subject Headings

  • White People
  • United States
  • Tobacco Smoking
  • Sex Factors
  • Odds Ratio
  • Obesity
  • Nutrition Surveys
  • Middle Aged
  • Marijuana Use
  • Male
 

Citation

APA
Chicago
ICMJE
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Skipina, T. M., Patel, N., Upadhya, B., & Soliman, E. Z. (2022). Relation of Cannabis Use to Elevated Atherosclerotic Cardiovascular Disease Risk Score. Am J Cardiol, 165, 46–50. https://doi.org/10.1016/j.amjcard.2021.10.051
Skipina, Travis M., Nikhil Patel, Bharathi Upadhya, and Elsayed Z. Soliman. “Relation of Cannabis Use to Elevated Atherosclerotic Cardiovascular Disease Risk Score.Am J Cardiol 165 (February 15, 2022): 46–50. https://doi.org/10.1016/j.amjcard.2021.10.051.
Skipina TM, Patel N, Upadhya B, Soliman EZ. Relation of Cannabis Use to Elevated Atherosclerotic Cardiovascular Disease Risk Score. Am J Cardiol. 2022 Feb 15;165:46–50.
Skipina, Travis M., et al. “Relation of Cannabis Use to Elevated Atherosclerotic Cardiovascular Disease Risk Score.Am J Cardiol, vol. 165, Feb. 2022, pp. 46–50. Pubmed, doi:10.1016/j.amjcard.2021.10.051.
Skipina TM, Patel N, Upadhya B, Soliman EZ. Relation of Cannabis Use to Elevated Atherosclerotic Cardiovascular Disease Risk Score. Am J Cardiol. 2022 Feb 15;165:46–50.
Journal cover image

Published In

Am J Cardiol

DOI

EISSN

1879-1913

Publication Date

February 15, 2022

Volume

165

Start / End Page

46 / 50

Location

United States

Related Subject Headings

  • White People
  • United States
  • Tobacco Smoking
  • Sex Factors
  • Odds Ratio
  • Obesity
  • Nutrition Surveys
  • Middle Aged
  • Marijuana Use
  • Male