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Parenchymal scarring is associated with restrictive spirometric defects in patients with chronic thromboembolic pulmonary hypertension.

Publication ,  Journal Article
Morris, TA; Auger, WR; Ysrael, MZ; Olson, LK; Channick, RN; Fedullo, PF; Moser, KM
Published in: Chest
August 1996

UNLABELLED: The finding of a restrictive pulmonary defect may divert clinicians from considering the diagnosis of chronic thromboembolic pulmonary hypertension because lung volumes are usually normal in this disorder. We have, however, encountered a significant number of these patients with reduced lung volumes. Furthermore, we have observed many patients who have developed parenchymal scars and/or pleural thickening. To determine whether such findings are associated with lung volume restriction, we analyzed patients evaluated at our institution for chronic thromboembolic pulmonary hypertension over a 20-month period in whom thoracic high-resolution CT scans and pulmonary function testing had been performed. Patients with obstructive or restrictive lung disease from another cause were excluded. We compared the presence of lung restriction (total lung capacity below 80% of predicted) with the extent of parenchymal scarring, pleural thickening, and pulmonary artery diameter on CT scans. Of 191 patients evaluated, 51 met criteria for entry. Eleven patients (22%) had lung restriction. Parenchymal scarring was highly associated with lung restriction (p = 0.01). Neither pleural thickening (p = 0.08) nor pulmonary artery diameter (p = 0.80) was associated with lung restriction. CONCLUSIONS: A significant number of patients with chronic thromboembolic pulmonary hypertension may have restrictive lung defects. The restriction may be due to parenchymal scarring.

Duke Scholars

Published In

Chest

DOI

ISSN

0012-3692

Publication Date

August 1996

Volume

110

Issue

2

Start / End Page

399 / 403

Location

United States

Related Subject Headings

  • Total Lung Capacity
  • Tomography, X-Ray Computed
  • Spirometry
  • Retrospective Studies
  • Respiratory System
  • Pulmonary Embolism
  • Pulmonary Artery
  • Pleura
  • Middle Aged
  • Male
 

Citation

APA
Chicago
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MLA
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Morris, T. A., Auger, W. R., Ysrael, M. Z., Olson, L. K., Channick, R. N., Fedullo, P. F., & Moser, K. M. (1996). Parenchymal scarring is associated with restrictive spirometric defects in patients with chronic thromboembolic pulmonary hypertension. Chest, 110(2), 399–403. https://doi.org/10.1378/chest.110.2.399
Morris, T. A., W. R. Auger, M. Z. Ysrael, L. K. Olson, R. N. Channick, P. F. Fedullo, and K. M. Moser. “Parenchymal scarring is associated with restrictive spirometric defects in patients with chronic thromboembolic pulmonary hypertension.Chest 110, no. 2 (August 1996): 399–403. https://doi.org/10.1378/chest.110.2.399.
Morris TA, Auger WR, Ysrael MZ, Olson LK, Channick RN, Fedullo PF, et al. Parenchymal scarring is associated with restrictive spirometric defects in patients with chronic thromboembolic pulmonary hypertension. Chest. 1996 Aug;110(2):399–403.
Morris, T. A., et al. “Parenchymal scarring is associated with restrictive spirometric defects in patients with chronic thromboembolic pulmonary hypertension.Chest, vol. 110, no. 2, Aug. 1996, pp. 399–403. Pubmed, doi:10.1378/chest.110.2.399.
Morris TA, Auger WR, Ysrael MZ, Olson LK, Channick RN, Fedullo PF, Moser KM. Parenchymal scarring is associated with restrictive spirometric defects in patients with chronic thromboembolic pulmonary hypertension. Chest. 1996 Aug;110(2):399–403.
Journal cover image

Published In

Chest

DOI

ISSN

0012-3692

Publication Date

August 1996

Volume

110

Issue

2

Start / End Page

399 / 403

Location

United States

Related Subject Headings

  • Total Lung Capacity
  • Tomography, X-Ray Computed
  • Spirometry
  • Retrospective Studies
  • Respiratory System
  • Pulmonary Embolism
  • Pulmonary Artery
  • Pleura
  • Middle Aged
  • Male