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Successful pulmonary thromboendarterectomy in two patients with sickle cell disease.

Publication ,  Journal Article
Yung, GL; Channick, RN; Fedullo, PF; Auger, WR; Kerr, KM; Jamieson, SW; Kapelanski, DP; Moser, KM
Published in: Am J Respir Crit Care Med
May 1998

Patients with sickle cell disease have been reported to have an increased risk of thromboembolism and pulmonary hypertension. Some of these patients may benefit from pulmonary thromboendarterectomy (PTE), a procedure that requires profound hypothermia, cardiopulmonary bypass, and periods of circulatory arrest, factors that may potentially increase the risk of sickling. Two patients with sickle cell disease (sickle-thalassemia [Hb S/beta+] and Hb SS) presented to the Pulmonary Vascular Center of UCSD Medical Center with significant shortness of breath and limitation of daily activities. Both of these patients were found to have surgically accessible chronic thromboembolic disease with pulmonary hypertension. PTE was performed in both patients using exchange transfusion, with avoidance of anemia, hypoxia, and acidosis. A successful outcome with resolution of pulmonary hypertension was achieved in both cases. To our knowledge this is the first report of patients with sickle cell disease who successfully underwent PTE for chronic thromboembolic pulmonary hypertension.

Duke Scholars

Published In

Am J Respir Crit Care Med

DOI

ISSN

1073-449X

Publication Date

May 1998

Volume

157

Issue

5 Pt 1

Start / End Page

1690 / 1693

Location

United States

Related Subject Headings

  • beta-Thalassemia
  • Respiratory System
  • Pulmonary Embolism
  • Pulmonary Artery
  • Preoperative Care
  • Postoperative Complications
  • Male
  • Humans
  • Female
  • Exchange Transfusion, Whole Blood
 

Citation

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MLA
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Yung, G. L., Channick, R. N., Fedullo, P. F., Auger, W. R., Kerr, K. M., Jamieson, S. W., … Moser, K. M. (1998). Successful pulmonary thromboendarterectomy in two patients with sickle cell disease. Am J Respir Crit Care Med, 157(5 Pt 1), 1690–1693. https://doi.org/10.1164/ajrccm.157.5.9710032
Yung, G. L., R. N. Channick, P. F. Fedullo, W. R. Auger, K. M. Kerr, S. W. Jamieson, D. P. Kapelanski, and K. M. Moser. “Successful pulmonary thromboendarterectomy in two patients with sickle cell disease.Am J Respir Crit Care Med 157, no. 5 Pt 1 (May 1998): 1690–93. https://doi.org/10.1164/ajrccm.157.5.9710032.
Yung GL, Channick RN, Fedullo PF, Auger WR, Kerr KM, Jamieson SW, et al. Successful pulmonary thromboendarterectomy in two patients with sickle cell disease. Am J Respir Crit Care Med. 1998 May;157(5 Pt 1):1690–3.
Yung, G. L., et al. “Successful pulmonary thromboendarterectomy in two patients with sickle cell disease.Am J Respir Crit Care Med, vol. 157, no. 5 Pt 1, May 1998, pp. 1690–93. Pubmed, doi:10.1164/ajrccm.157.5.9710032.
Yung GL, Channick RN, Fedullo PF, Auger WR, Kerr KM, Jamieson SW, Kapelanski DP, Moser KM. Successful pulmonary thromboendarterectomy in two patients with sickle cell disease. Am J Respir Crit Care Med. 1998 May;157(5 Pt 1):1690–1693.

Published In

Am J Respir Crit Care Med

DOI

ISSN

1073-449X

Publication Date

May 1998

Volume

157

Issue

5 Pt 1

Start / End Page

1690 / 1693

Location

United States

Related Subject Headings

  • beta-Thalassemia
  • Respiratory System
  • Pulmonary Embolism
  • Pulmonary Artery
  • Preoperative Care
  • Postoperative Complications
  • Male
  • Humans
  • Female
  • Exchange Transfusion, Whole Blood