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Age-related impairments in object-place associations are not due to hippocampal dysfunction.

Publication ,  Journal Article
Hernandez, AR; Maurer, AP; Reasor, JE; Turner, SM; Barthle, SE; Johnson, SA; Burke, SN
Published in: Behav Neurosci
October 2015

Age-associated cognitive decline can reduce an individual's quality of life. As no single neurobiological deficit can account for the wide spectrum of behavioral impairments observed in old age, it is critical to develop an understanding of how interactions between different brain regions change over the life span. The performance of young and aged animals on behaviors that require the hippocampus and cortical regions to interact, however, has not been well characterized. Specifically, the ability to link a spatial location with specific features of a stimulus, such as object identity, relies on the hippocampus, perirhinal and prefrontal cortices. Although aging is associated with dysfunction in each of these brain regions, behavioral measures of functional change within the hippocampus, perirhinal and prefrontal cortices in individual animals are often not correlated. Thus, how dysfunction of a single brain region within this circuit, such as the hippocampus, impacts behaviors that require communication with the perirhinal and prefrontal cortices remains unknown. To address this question, young and aged rats were tested on the interregion dependent object-place paired association task, as well as a hippocampal-dependent test of spatial reference memory. This particular cohort of aged rats did not show deficits on the hippocampal-dependent task, but were significantly impaired at acquiring object-place associations relative to young. These data suggest that behaviors requiring functional connectivity across different regions of the memory network may be particularly sensitive to aging, and can be used to develop models that will clarify the impact of systems-level dysfunction in the elderly.

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Published In

Behav Neurosci

DOI

EISSN

1939-0084

Publication Date

October 2015

Volume

129

Issue

5

Start / End Page

599 / 610

Location

United States

Related Subject Headings

  • Spatial Navigation
  • Spatial Behavior
  • Space Perception
  • Recognition, Psychology
  • Rats
  • Quality of Life
  • Memory
  • Maze Learning
  • Male
  • Learning
 

Citation

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Hernandez, A. R., Maurer, A. P., Reasor, J. E., Turner, S. M., Barthle, S. E., Johnson, S. A., & Burke, S. N. (2015). Age-related impairments in object-place associations are not due to hippocampal dysfunction. Behav Neurosci, 129(5), 599–610. https://doi.org/10.1037/bne0000093
Hernandez, Abigail R., Andrew P. Maurer, Jordan E. Reasor, Sean M. Turner, Sarah E. Barthle, Sarah A. Johnson, and Sara N. Burke. “Age-related impairments in object-place associations are not due to hippocampal dysfunction.Behav Neurosci 129, no. 5 (October 2015): 599–610. https://doi.org/10.1037/bne0000093.
Hernandez AR, Maurer AP, Reasor JE, Turner SM, Barthle SE, Johnson SA, et al. Age-related impairments in object-place associations are not due to hippocampal dysfunction. Behav Neurosci. 2015 Oct;129(5):599–610.
Hernandez, Abigail R., et al. “Age-related impairments in object-place associations are not due to hippocampal dysfunction.Behav Neurosci, vol. 129, no. 5, Oct. 2015, pp. 599–610. Pubmed, doi:10.1037/bne0000093.
Hernandez AR, Maurer AP, Reasor JE, Turner SM, Barthle SE, Johnson SA, Burke SN. Age-related impairments in object-place associations are not due to hippocampal dysfunction. Behav Neurosci. 2015 Oct;129(5):599–610.

Published In

Behav Neurosci

DOI

EISSN

1939-0084

Publication Date

October 2015

Volume

129

Issue

5

Start / End Page

599 / 610

Location

United States

Related Subject Headings

  • Spatial Navigation
  • Spatial Behavior
  • Space Perception
  • Recognition, Psychology
  • Rats
  • Quality of Life
  • Memory
  • Maze Learning
  • Male
  • Learning