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Caspases and IAPs: a dance of death ensures cell survival.

Publication ,  Journal Article
Galbán, S; Brady, GF; Duckett, CS
Published in: Mol Cell
November 21, 2008
Published version (DOI) Link to item

In this issue of Molecular Cell, Ditzel et al. (2008) show that DIAP1 polyubiquitinates DRONC, DCP-1, and drICE, leading to their nondegradative inactivation. Surprisingly, activation of DIAP1 requires caspase-mediated cleavage, revealing an elegant feedback mechanism by which caspases regulate their own fate.

Duke Scholars

Colin S Duckett
Author Colin S Duckett Pathology

Published In

Mol Cell

DOI

10.1016/j.molcel.2008.11.005

EISSN

1097-4164

Publication Date

November 21, 2008

Volume

32

Issue

4

Start / End Page

462 / 463

Location

United States

Related Subject Headings

  • Ubiquitination
  • Models, Biological
  • Inhibitor of Apoptosis Proteins
  • Feedback, Physiological
  • Drosophila
  • Developmental Biology
  • Cell Survival
  • Caspases
  • Apoptosis
  • Animals
 

Citation

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ICMJE
MLA
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Galbán, S., Brady, G. F., & Duckett, C. S. (2008). Caspases and IAPs: a dance of death ensures cell survival. Mol Cell, 32(4), 462–463. https://doi.org/10.1016/j.molcel.2008.11.005
Galbán, Stefanie, Graham F. Brady, and Colin S. Duckett. “Caspases and IAPs: a dance of death ensures cell survival.” Mol Cell 32, no. 4 (November 21, 2008): 462–63. https://doi.org/10.1016/j.molcel.2008.11.005.
Galbán S, Brady GF, Duckett CS. Caspases and IAPs: a dance of death ensures cell survival. Mol Cell. 2008 Nov 21;32(4):462–3.
Galbán, Stefanie, et al. “Caspases and IAPs: a dance of death ensures cell survival.” Mol Cell, vol. 32, no. 4, Nov. 2008, pp. 462–63. Pubmed, doi:10.1016/j.molcel.2008.11.005.
Galbán S, Brady GF, Duckett CS. Caspases and IAPs: a dance of death ensures cell survival. Mol Cell. 2008 Nov 21;32(4):462–463.
Journal cover image

Published In

Mol Cell

DOI

10.1016/j.molcel.2008.11.005

EISSN

1097-4164

Publication Date

November 21, 2008

Volume

32

Issue

4

Start / End Page

462 / 463

Location

United States

Related Subject Headings

  • Ubiquitination
  • Models, Biological
  • Inhibitor of Apoptosis Proteins
  • Feedback, Physiological
  • Drosophila
  • Developmental Biology
  • Cell Survival
  • Caspases
  • Apoptosis
  • Animals