COMMD proteins, a novel family of structural and functional homologs of MURR1.
MURR1 is a multifunctional protein that inhibits nuclear factor kappaB (NF-kappaB), a transcription factor with pleiotropic functions affecting innate and adaptive immunity, apoptosis, cell cycle regulation, and oncogenesis. Here we report the discovery of a new family of proteins with homology to MURR1. These proteins form multimeric complexes and were identified in a biochemical screen for MURR1-associated factors. The family is defined by the presence of a conserved and unique motif termed the COMM (copper metabolism gene MURR1) domain, which functions as an interface for protein-protein interactions. Like MURR1, several of these factors also associate with and inhibit NF-kappaB. The proteins designated as COMMD or COMM domain containing 1-10 are extensively conserved in multicellular eukaryotic organisms and define a novel family of structural and functional homologs of MURR1. The prototype of this family, MURR1/COMMD1, suppresses NF-kappaB not by affecting nuclear translocation or binding of NF-kappaB to cognate motifs; rather, it functions in the nucleus by affecting the association of NF-kappaB with chromatin.
Duke Scholars
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Related Subject Headings
- Transfection
- Subcellular Fractions
- Sequence Homology, Amino Acid
- Reverse Transcriptase Polymerase Chain Reaction
- Proteins
- Protein Structure, Tertiary
- Protein Binding
- Plasmids
- NF-kappa B
- Molecular Sequence Data
Citation
Published In
DOI
ISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- Transfection
- Subcellular Fractions
- Sequence Homology, Amino Acid
- Reverse Transcriptase Polymerase Chain Reaction
- Proteins
- Protein Structure, Tertiary
- Protein Binding
- Plasmids
- NF-kappa B
- Molecular Sequence Data