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COMMD proteins, a novel family of structural and functional homologs of MURR1.

Publication ,  Journal Article
Burstein, E; Hoberg, JE; Wilkinson, AS; Rumble, JM; Csomos, RA; Komarck, CM; Maine, GN; Wilkinson, JC; Mayo, MW; Duckett, CS
Published in: J Biol Chem
June 10, 2005

MURR1 is a multifunctional protein that inhibits nuclear factor kappaB (NF-kappaB), a transcription factor with pleiotropic functions affecting innate and adaptive immunity, apoptosis, cell cycle regulation, and oncogenesis. Here we report the discovery of a new family of proteins with homology to MURR1. These proteins form multimeric complexes and were identified in a biochemical screen for MURR1-associated factors. The family is defined by the presence of a conserved and unique motif termed the COMM (copper metabolism gene MURR1) domain, which functions as an interface for protein-protein interactions. Like MURR1, several of these factors also associate with and inhibit NF-kappaB. The proteins designated as COMMD or COMM domain containing 1-10 are extensively conserved in multicellular eukaryotic organisms and define a novel family of structural and functional homologs of MURR1. The prototype of this family, MURR1/COMMD1, suppresses NF-kappaB not by affecting nuclear translocation or binding of NF-kappaB to cognate motifs; rather, it functions in the nucleus by affecting the association of NF-kappaB with chromatin.

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Published In

J Biol Chem

DOI

ISSN

0021-9258

Publication Date

June 10, 2005

Volume

280

Issue

23

Start / End Page

22222 / 22232

Location

United States

Related Subject Headings

  • Transfection
  • Subcellular Fractions
  • Sequence Homology, Amino Acid
  • Reverse Transcriptase Polymerase Chain Reaction
  • Proteins
  • Protein Structure, Tertiary
  • Protein Binding
  • Plasmids
  • NF-kappa B
  • Molecular Sequence Data
 

Citation

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Burstein, E., Hoberg, J. E., Wilkinson, A. S., Rumble, J. M., Csomos, R. A., Komarck, C. M., … Duckett, C. S. (2005). COMMD proteins, a novel family of structural and functional homologs of MURR1. J Biol Chem, 280(23), 22222–22232. https://doi.org/10.1074/jbc.M501928200
Burstein, Ezra, Jamie E. Hoberg, Amanda S. Wilkinson, Julie M. Rumble, Rebecca A. Csomos, Christine M. Komarck, Gabriel N. Maine, John C. Wilkinson, Marty W. Mayo, and Colin S. Duckett. “COMMD proteins, a novel family of structural and functional homologs of MURR1.J Biol Chem 280, no. 23 (June 10, 2005): 22222–32. https://doi.org/10.1074/jbc.M501928200.
Burstein E, Hoberg JE, Wilkinson AS, Rumble JM, Csomos RA, Komarck CM, et al. COMMD proteins, a novel family of structural and functional homologs of MURR1. J Biol Chem. 2005 Jun 10;280(23):22222–32.
Burstein, Ezra, et al. “COMMD proteins, a novel family of structural and functional homologs of MURR1.J Biol Chem, vol. 280, no. 23, June 2005, pp. 22222–32. Pubmed, doi:10.1074/jbc.M501928200.
Burstein E, Hoberg JE, Wilkinson AS, Rumble JM, Csomos RA, Komarck CM, Maine GN, Wilkinson JC, Mayo MW, Duckett CS. COMMD proteins, a novel family of structural and functional homologs of MURR1. J Biol Chem. 2005 Jun 10;280(23):22222–22232.

Published In

J Biol Chem

DOI

ISSN

0021-9258

Publication Date

June 10, 2005

Volume

280

Issue

23

Start / End Page

22222 / 22232

Location

United States

Related Subject Headings

  • Transfection
  • Subcellular Fractions
  • Sequence Homology, Amino Acid
  • Reverse Transcriptase Polymerase Chain Reaction
  • Proteins
  • Protein Structure, Tertiary
  • Protein Binding
  • Plasmids
  • NF-kappa B
  • Molecular Sequence Data