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A caspase homolog keeps CED-3 in check.

Publication ,  Journal Article
Brady, GF; Duckett, CS
Published in: Trends Biochem Sci
March 2009

Apoptosis is a highly conserved form of cell death that is essential for controlling cell numbers throughout the lifetime of an organism. In Caenorhabditis elegans, the final step in the apoptotic cascade is activation of the death-inducing protease CED-3. Until now, no direct negative regulators of CED-3 had been identified, so the mechanism for maintaining a proper life-death balance was unclear. Now, a new study identifies CSP-3 as an important negative regulator of CED-3 during C. elegans development.

Duke Scholars

Published In

Trends Biochem Sci

DOI

ISSN

0968-0004

Publication Date

March 2009

Volume

34

Issue

3

Start / End Page

104 / 107

Location

England

Related Subject Headings

  • Protein Binding
  • Models, Biological
  • Enzyme Activation
  • Developmental Biology
  • Caspases
  • Caenorhabditis elegans Proteins
  • Caenorhabditis elegans
  • Apoptosis
  • Animals
  • 3404 Medicinal and biomolecular chemistry
 

Citation

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Brady, G. F., & Duckett, C. S. (2009). A caspase homolog keeps CED-3 in check. Trends Biochem Sci, 34(3), 104–107. https://doi.org/10.1016/j.tibs.2008.11.003
Brady, Graham F., and Colin S. Duckett. “A caspase homolog keeps CED-3 in check.Trends Biochem Sci 34, no. 3 (March 2009): 104–7. https://doi.org/10.1016/j.tibs.2008.11.003.
Brady GF, Duckett CS. A caspase homolog keeps CED-3 in check. Trends Biochem Sci. 2009 Mar;34(3):104–7.
Brady, Graham F., and Colin S. Duckett. “A caspase homolog keeps CED-3 in check.Trends Biochem Sci, vol. 34, no. 3, Mar. 2009, pp. 104–07. Pubmed, doi:10.1016/j.tibs.2008.11.003.
Brady GF, Duckett CS. A caspase homolog keeps CED-3 in check. Trends Biochem Sci. 2009 Mar;34(3):104–107.
Journal cover image

Published In

Trends Biochem Sci

DOI

ISSN

0968-0004

Publication Date

March 2009

Volume

34

Issue

3

Start / End Page

104 / 107

Location

England

Related Subject Headings

  • Protein Binding
  • Models, Biological
  • Enzyme Activation
  • Developmental Biology
  • Caspases
  • Caenorhabditis elegans Proteins
  • Caenorhabditis elegans
  • Apoptosis
  • Animals
  • 3404 Medicinal and biomolecular chemistry