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Inhibitor of apoptosis proteins in eukaryotic evolution and development: a model of thematic conservation.

Publication ,  Journal Article
O'Riordan, MXD; Bauler, LD; Scott, FL; Duckett, CS
Published in: Dev Cell
October 2008

The past decade and a half has witnessed the discovery of a large, evolutionarily conserved family of cellular genes bearing homology to the prototype baculovirus Inhibitor of Apoptosis (IAP). The logical decision in the field to also refer to these cellular proteins as IAPs fails to do justice to this versatile group of factors that play a wide range of roles in eukaryotic development and homeostasis which include, but are not limited to, the regulation of programmed cell death. Here we describe the shared functional characteristics of several well-characterized IAPs whose defining motifs place them more in the category of multifunctional modular protein interaction domains.

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Published In

Dev Cell

DOI

EISSN

1878-1551

Publication Date

October 2008

Volume

15

Issue

4

Start / End Page

497 / 508

Location

United States

Related Subject Headings

  • Sequence Homology, Amino Acid
  • Protein Structure, Tertiary
  • Protein Binding
  • Molecular Sequence Data
  • Models, Biological
  • Inhibitor of Apoptosis Proteins
  • Evolution, Molecular
  • Developmental Biology
  • Caspases
  • Apoptosis
 

Citation

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O’Riordan, M. X. D., Bauler, L. D., Scott, F. L., & Duckett, C. S. (2008). Inhibitor of apoptosis proteins in eukaryotic evolution and development: a model of thematic conservation. Dev Cell, 15(4), 497–508. https://doi.org/10.1016/j.devcel.2008.09.012
O’Riordan, Mary X. D., Laura D. Bauler, Fiona L. Scott, and Colin S. Duckett. “Inhibitor of apoptosis proteins in eukaryotic evolution and development: a model of thematic conservation.Dev Cell 15, no. 4 (October 2008): 497–508. https://doi.org/10.1016/j.devcel.2008.09.012.
O’Riordan MXD, Bauler LD, Scott FL, Duckett CS. Inhibitor of apoptosis proteins in eukaryotic evolution and development: a model of thematic conservation. Dev Cell. 2008 Oct;15(4):497–508.
O’Riordan, Mary X. D., et al. “Inhibitor of apoptosis proteins in eukaryotic evolution and development: a model of thematic conservation.Dev Cell, vol. 15, no. 4, Oct. 2008, pp. 497–508. Pubmed, doi:10.1016/j.devcel.2008.09.012.
O’Riordan MXD, Bauler LD, Scott FL, Duckett CS. Inhibitor of apoptosis proteins in eukaryotic evolution and development: a model of thematic conservation. Dev Cell. 2008 Oct;15(4):497–508.
Journal cover image

Published In

Dev Cell

DOI

EISSN

1878-1551

Publication Date

October 2008

Volume

15

Issue

4

Start / End Page

497 / 508

Location

United States

Related Subject Headings

  • Sequence Homology, Amino Acid
  • Protein Structure, Tertiary
  • Protein Binding
  • Molecular Sequence Data
  • Models, Biological
  • Inhibitor of Apoptosis Proteins
  • Evolution, Molecular
  • Developmental Biology
  • Caspases
  • Apoptosis