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Apoptotic sensitivity of murine IAP-deficient cells.

Publication ,  Journal Article
Rumble, JM; Bertrand, MJM; Csomos, RA; Wright, CW; Albert, L; Mak, TW; Barker, PA; Duckett, CS
Published in: Biochem J
October 1, 2008

Although numerous studies have implicated the IAPs (inhibitor of apoptosis proteins) in the control of apoptotic cell death, analyses of murine Iap-targeted cells have not revealed significant differences in their susceptibility to apoptosis. In the present study, we show that, under defined conditions, murine cells lacking XIAP (X-linked inhibitor of apoptosis) and c-IAP (cellular IAP) 2, but not c-IAP1, exhibit heightened apoptotic sensitivity to both intrinsic and extrinsic apoptotic stimuli.

Duke Scholars

Published In

Biochem J

DOI

EISSN

1470-8728

Publication Date

October 1, 2008

Volume

415

Issue

1

Start / End Page

21 / 25

Location

England

Related Subject Headings

  • X-Linked Inhibitor of Apoptosis Protein
  • Mice
  • Male
  • Inhibitor of Apoptosis Proteins
  • Biochemistry & Molecular Biology
  • Apoptosis
  • Animals
  • 3101 Biochemistry and cell biology
  • 11 Medical and Health Sciences
  • 06 Biological Sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Rumble, J. M., Bertrand, M. J. M., Csomos, R. A., Wright, C. W., Albert, L., Mak, T. W., … Duckett, C. S. (2008). Apoptotic sensitivity of murine IAP-deficient cells. Biochem J, 415(1), 21–25. https://doi.org/10.1042/BJ20081188
Rumble, Julie M., Mathieu J. M. Bertrand, Rebecca A. Csomos, Casey W. Wright, Lori Albert, Tak W. Mak, Philip A. Barker, and Colin S. Duckett. “Apoptotic sensitivity of murine IAP-deficient cells.Biochem J 415, no. 1 (October 1, 2008): 21–25. https://doi.org/10.1042/BJ20081188.
Rumble JM, Bertrand MJM, Csomos RA, Wright CW, Albert L, Mak TW, et al. Apoptotic sensitivity of murine IAP-deficient cells. Biochem J. 2008 Oct 1;415(1):21–5.
Rumble, Julie M., et al. “Apoptotic sensitivity of murine IAP-deficient cells.Biochem J, vol. 415, no. 1, Oct. 2008, pp. 21–25. Pubmed, doi:10.1042/BJ20081188.
Rumble JM, Bertrand MJM, Csomos RA, Wright CW, Albert L, Mak TW, Barker PA, Duckett CS. Apoptotic sensitivity of murine IAP-deficient cells. Biochem J. 2008 Oct 1;415(1):21–25.

Published In

Biochem J

DOI

EISSN

1470-8728

Publication Date

October 1, 2008

Volume

415

Issue

1

Start / End Page

21 / 25

Location

England

Related Subject Headings

  • X-Linked Inhibitor of Apoptosis Protein
  • Mice
  • Male
  • Inhibitor of Apoptosis Proteins
  • Biochemistry & Molecular Biology
  • Apoptosis
  • Animals
  • 3101 Biochemistry and cell biology
  • 11 Medical and Health Sciences
  • 06 Biological Sciences