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SIRT1 Activation Promotes Long-Term Functional Recovery After Subarachnoid Hemorrhage in Rats.

Publication ,  Journal Article
Chu, D; Li, X; Qu, X; Diwan, D; Warner, DS; Zipfel, GJ; Sheng, H
Published in: Neurocrit Care
June 2023

BACKGROUND: An increase in sirtuin 1 (SIRT1) reportedly attenuates early brain injury, delayed cerebral ischemia, and short-term neurologic deficits in rodent models of subarachnoid hemorrhage (SAH). This study investigates the effect of resveratrol, a SIRT1 activator, on long-term functional recovery in a clinically relevant rat model of SAH. METHODS: Thirty male Wistar rats were subjected to fresh arterial blood injection into the prechiasmatic space and randomized to receive 7 days of intraperitoneal resveratrol (20 mg/kg) or vehicle injections. Body weight and rotarod performance were measured on days 0, 3, 7, and 34 post SAH. The neurologic score was assessed 7 and 34 days post SAH. Morris water maze performance was evaluated 29-33 days post SAH. Brain SIRT1 activity and CA1 neuronal survival were also assessed. RESULTS: Blood pressure rapidly increased in all SAH rats, and no between-group differences in blood pressure, blood gases, or glucose were detected. SAH induced weight loss during the first 7 days, which gradually recovered in both groups. Neurologic score and rotarod performance were significantly improved after resveratrol treatment at 34 days post SAH (p = 0.01 and 0.04, respectively). Latency to find the Morris water maze hidden platform was shortened (p = 0.02). In the resveratrol group, more CA1 neurons survived following SAH (p = 0.1). An increase in brain SIRT1 activity was confirmed in the resveratrol group (p < 0.05). CONCLUSIONS: Treatment with resveratrol for 1 week significantly improved the neurologic score, rotarod performance, and latency to find the Morris water maze hidden platform 34 days post SAH. These findings indicate that SIRT1 activation warrants further investigation as a mechanistic target for SAH therapy.

Duke Scholars

Published In

Neurocrit Care

DOI

EISSN

1556-0961

Publication Date

June 2023

Volume

38

Issue

3

Start / End Page

622 / 632

Location

United States

Related Subject Headings

  • Subarachnoid Hemorrhage
  • Sirtuin 1
  • Resveratrol
  • Rats, Wistar
  • Rats
  • Neurology & Neurosurgery
  • Male
  • Disease Models, Animal
  • Brain Injuries
  • Animals
 

Citation

APA
Chicago
ICMJE
MLA
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Chu, D., Li, X., Qu, X., Diwan, D., Warner, D. S., Zipfel, G. J., & Sheng, H. (2023). SIRT1 Activation Promotes Long-Term Functional Recovery After Subarachnoid Hemorrhage in Rats. Neurocrit Care, 38(3), 622–632. https://doi.org/10.1007/s12028-022-01614-z
Chu, Dongmei, Xuan Li, Xingguang Qu, Deepti Diwan, David S. Warner, Gregory J. Zipfel, and Huaxin Sheng. “SIRT1 Activation Promotes Long-Term Functional Recovery After Subarachnoid Hemorrhage in Rats.Neurocrit Care 38, no. 3 (June 2023): 622–32. https://doi.org/10.1007/s12028-022-01614-z.
Chu D, Li X, Qu X, Diwan D, Warner DS, Zipfel GJ, et al. SIRT1 Activation Promotes Long-Term Functional Recovery After Subarachnoid Hemorrhage in Rats. Neurocrit Care. 2023 Jun;38(3):622–32.
Chu, Dongmei, et al. “SIRT1 Activation Promotes Long-Term Functional Recovery After Subarachnoid Hemorrhage in Rats.Neurocrit Care, vol. 38, no. 3, June 2023, pp. 622–32. Pubmed, doi:10.1007/s12028-022-01614-z.
Chu D, Li X, Qu X, Diwan D, Warner DS, Zipfel GJ, Sheng H. SIRT1 Activation Promotes Long-Term Functional Recovery After Subarachnoid Hemorrhage in Rats. Neurocrit Care. 2023 Jun;38(3):622–632.
Journal cover image

Published In

Neurocrit Care

DOI

EISSN

1556-0961

Publication Date

June 2023

Volume

38

Issue

3

Start / End Page

622 / 632

Location

United States

Related Subject Headings

  • Subarachnoid Hemorrhage
  • Sirtuin 1
  • Resveratrol
  • Rats, Wistar
  • Rats
  • Neurology & Neurosurgery
  • Male
  • Disease Models, Animal
  • Brain Injuries
  • Animals