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Nebulized mRNA-Encoded Antibodies Protect Hamsters from SARS-CoV-2 Infection.

Publication ,  Journal Article
Vanover, D; Zurla, C; Peck, HE; Orr-Burks, N; Joo, JY; Murray, J; Holladay, N; Hobbs, RA; Jung, Y; Chaves, LCS; Rotolo, L; Lifland, AW; Li, D ...
Published in: Adv Sci (Weinh)
December 2022

Despite the success of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) vaccines, there remains a clear need for new classes of preventatives for respiratory viral infections due to vaccine hesitancy, lack of sterilizing immunity, and for at-risk patient populations, including the immunocompromised. While many neutralizing antibodies have been identified, and several approved, to treat COVID-19, systemic delivery, large doses, and high costs have the potential to limit their widespread use, especially in low- and middle-income countries. To use these antibodies more efficiently, an inhalable formulation is developed that allows for the expression of mRNA-encoded, membrane-anchored neutralizing antibodies in the lung to mitigate SARS-CoV-2 infections. First, the ability of mRNA-encoded, membrane-anchored, anti-SARS-CoV-2 antibodies to prevent infections in vitro is demonstrated. Next, it is demonstrated that nebulizer-based delivery of these mRNA-expressed neutralizing antibodies potently abrogates disease in the hamster model. Overall, these results support the use of nebulizer-based mRNA expression of neutralizing antibodies as a new paradigm for mitigating respiratory virus infections.

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Published In

Adv Sci (Weinh)

DOI

EISSN

2198-3844

Publication Date

December 2022

Volume

9

Issue

34

Start / End Page

e2202771

Location

Germany

Related Subject Headings

  • SARS-CoV-2
  • RNA, Messenger
  • Humans
  • COVID-19
  • Antibodies, Neutralizing
 

Citation

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Vanover, D., Zurla, C., Peck, H. E., Orr-Burks, N., Joo, J. Y., Murray, J., … Santangelo, P. J. (2022). Nebulized mRNA-Encoded Antibodies Protect Hamsters from SARS-CoV-2 Infection. Adv Sci (Weinh), 9(34), e2202771. https://doi.org/10.1002/advs.202202771
Vanover, Daryll, Chiara Zurla, Hannah E. Peck, Nichole Orr-Burks, Jae Yeon Joo, Jackelyn Murray, Nathan Holladay, et al. “Nebulized mRNA-Encoded Antibodies Protect Hamsters from SARS-CoV-2 Infection.Adv Sci (Weinh) 9, no. 34 (December 2022): e2202771. https://doi.org/10.1002/advs.202202771.
Vanover D, Zurla C, Peck HE, Orr-Burks N, Joo JY, Murray J, et al. Nebulized mRNA-Encoded Antibodies Protect Hamsters from SARS-CoV-2 Infection. Adv Sci (Weinh). 2022 Dec;9(34):e2202771.
Vanover, Daryll, et al. “Nebulized mRNA-Encoded Antibodies Protect Hamsters from SARS-CoV-2 Infection.Adv Sci (Weinh), vol. 9, no. 34, Dec. 2022, p. e2202771. Pubmed, doi:10.1002/advs.202202771.
Vanover D, Zurla C, Peck HE, Orr-Burks N, Joo JY, Murray J, Holladay N, Hobbs RA, Jung Y, Chaves LCS, Rotolo L, Lifland AW, Olivier AK, Li D, Saunders KO, Sempowski GD, Crowe JE, Haynes BF, Lafontaine ER, Hogan RJ, Santangelo PJ. Nebulized mRNA-Encoded Antibodies Protect Hamsters from SARS-CoV-2 Infection. Adv Sci (Weinh). 2022 Dec;9(34):e2202771.
Journal cover image

Published In

Adv Sci (Weinh)

DOI

EISSN

2198-3844

Publication Date

December 2022

Volume

9

Issue

34

Start / End Page

e2202771

Location

Germany

Related Subject Headings

  • SARS-CoV-2
  • RNA, Messenger
  • Humans
  • COVID-19
  • Antibodies, Neutralizing