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Microglia states and nomenclature: A field at its crossroads.

Publication ,  Journal Article
Paolicelli, RC; Sierra, A; Stevens, B; Tremblay, M-E; Aguzzi, A; Ajami, B; Amit, I; Audinat, E; Bechmann, I; Bennett, M; Bennett, F; Bessis, A ...
Published in: Neuron
November 2022

Microglial research has advanced considerably in recent decades yet has been constrained by a rolling series of dichotomies such as "resting versus activated" and "M1 versus M2." This dualistic classification of good or bad microglia is inconsistent with the wide repertoire of microglial states and functions in development, plasticity, aging, and diseases that were elucidated in recent years. New designations continuously arising in an attempt to describe the different microglial states, notably defined using transcriptomics and proteomics, may easily lead to a misleading, although unintentional, coupling of categories and functions. To address these issues, we assembled a group of multidisciplinary experts to discuss our current understanding of microglial states as a dynamic concept and the importance of addressing microglial function. Here, we provide a conceptual framework and recommendations on the use of microglial nomenclature for researchers, reviewers, and editors, which will serve as the foundations for a future white paper.

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Published In

Neuron

DOI

EISSN

1097-4199

ISSN

0896-6273

Publication Date

November 2022

Volume

110

Issue

21

Start / End Page

3458 / 3483

Related Subject Headings

  • Neurology & Neurosurgery
  • Microglia
  • 5202 Biological psychology
  • 3209 Neurosciences
  • 1702 Cognitive Sciences
  • 1701 Psychology
  • 1109 Neurosciences
 

Citation

APA
Chicago
ICMJE
MLA
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Paolicelli, R. C., Sierra, A., Stevens, B., Tremblay, M.-E., Aguzzi, A., Ajami, B., … Wyss-Coray, T. (2022). Microglia states and nomenclature: A field at its crossroads. Neuron, 110(21), 3458–3483. https://doi.org/10.1016/j.neuron.2022.10.020
Paolicelli, Rosa C., Amanda Sierra, Beth Stevens, Marie-Eve Tremblay, Adriano Aguzzi, Bahareh Ajami, Ido Amit, et al. “Microglia states and nomenclature: A field at its crossroads.Neuron 110, no. 21 (November 2022): 3458–83. https://doi.org/10.1016/j.neuron.2022.10.020.
Paolicelli RC, Sierra A, Stevens B, Tremblay M-E, Aguzzi A, Ajami B, et al. Microglia states and nomenclature: A field at its crossroads. Neuron. 2022 Nov;110(21):3458–83.
Paolicelli, Rosa C., et al. “Microglia states and nomenclature: A field at its crossroads.Neuron, vol. 110, no. 21, Nov. 2022, pp. 3458–83. Epmc, doi:10.1016/j.neuron.2022.10.020.
Paolicelli RC, Sierra A, Stevens B, Tremblay M-E, Aguzzi A, Ajami B, Amit I, Audinat E, Bechmann I, Bennett M, Bennett F, Bessis A, Biber K, Bilbo S, Blurton-Jones M, Boddeke E, Brites D, Brône B, Brown GC, Butovsky O, Carson MJ, Castellano B, Colonna M, Cowley SA, Cunningham C, Davalos D, De Jager PL, de Strooper B, Denes A, Eggen BJL, Eyo U, Galea E, Garel S, Ginhoux F, Glass CK, Gokce O, Gomez-Nicola D, González B, Gordon S, Graeber MB, Greenhalgh AD, Gressens P, Greter M, Gutmann DH, Haass C, Heneka MT, Heppner FL, Hong S, Hume DA, Jung S, Kettenmann H, Kipnis J, Koyama R, Lemke G, Lynch M, Majewska A, Malcangio M, Malm T, Mancuso R, Masuda T, Matteoli M, McColl BW, Miron VE, Molofsky AV, Monje M, Mracsko E, Nadjar A, Neher JJ, Neniskyte U, Neumann H, Noda M, Peng B, Peri F, Perry VH, Popovich PG, Pridans C, Priller J, Prinz M, Ragozzino D, Ransohoff RM, Salter MW, Schaefer A, Schafer DP, Schwartz M, Simons M, Smith CJ, Streit WJ, Tay TL, Tsai L-H, Verkhratsky A, von Bernhardi R, Wake H, Wittamer V, Wolf SA, Wu L-J, Wyss-Coray T. Microglia states and nomenclature: A field at its crossroads. Neuron. 2022 Nov;110(21):3458–3483.
Journal cover image

Published In

Neuron

DOI

EISSN

1097-4199

ISSN

0896-6273

Publication Date

November 2022

Volume

110

Issue

21

Start / End Page

3458 / 3483

Related Subject Headings

  • Neurology & Neurosurgery
  • Microglia
  • 5202 Biological psychology
  • 3209 Neurosciences
  • 1702 Cognitive Sciences
  • 1701 Psychology
  • 1109 Neurosciences