The Inflamma-type: a patient phenotype characterized by a dysregulated inflammatory response after lower extremity articular fracture.
Publication
, Journal Article
Jacobs, CA; Olsen, ZM; Marchand, LS; Kraus, VB; Anderson, DD; Haller, J
Published in: Inflamm Res
January 2023
Synovial fluid was collected from 113 patients who had suffered tibial plateau (n = 48), tibial plafond (n = 29), or rotational ankle fractures (n = 36). Concentrations of IL-1β, IL-1RA, IL-6, IL-8, IL-10, and MMP-1, -3, and -13 were quantified using multiplex assays. A cluster analysis of synovial fluid biomarker concentrations was performed. Patient demographics, fracture type, Injury Severity Score (ISS), Charlson Comorbidity Index (CCI), and biomarker concentrations were compared between clusters. A subset of patients demonstrated a dysregulated inflammatory response after articular fracture including elevated pro-inflammatory cytokines and degradative enzymes previously linked to the development of post-traumatic osteoarthritis.
Duke Scholars
Published In
Inflamm Res
DOI
EISSN
1420-908X
Publication Date
January 2023
Volume
72
Issue
1
Start / End Page
9 / 11
Location
Switzerland
Related Subject Headings
- Synovial Fluid
- Phenotype
- Lower Extremity
- Immunology
- Cytokines
- Biomarkers
- 3202 Clinical sciences
- 1103 Clinical Sciences
Citation
APA
Chicago
ICMJE
MLA
NLM
Jacobs, C. A., Olsen, Z. M., Marchand, L. S., Kraus, V. B., Anderson, D. D., & Haller, J. (2023). The Inflamma-type: a patient phenotype characterized by a dysregulated inflammatory response after lower extremity articular fracture. Inflamm Res, 72(1), 9–11. https://doi.org/10.1007/s00011-022-01661-4
Jacobs, Cale A., Zachary M. Olsen, Lucas S. Marchand, Virginia B. Kraus, Donald D. Anderson, and Justin Haller. “The Inflamma-type: a patient phenotype characterized by a dysregulated inflammatory response after lower extremity articular fracture.” Inflamm Res 72, no. 1 (January 2023): 9–11. https://doi.org/10.1007/s00011-022-01661-4.
Jacobs CA, Olsen ZM, Marchand LS, Kraus VB, Anderson DD, Haller J. The Inflamma-type: a patient phenotype characterized by a dysregulated inflammatory response after lower extremity articular fracture. Inflamm Res. 2023 Jan;72(1):9–11.
Jacobs, Cale A., et al. “The Inflamma-type: a patient phenotype characterized by a dysregulated inflammatory response after lower extremity articular fracture.” Inflamm Res, vol. 72, no. 1, Jan. 2023, pp. 9–11. Pubmed, doi:10.1007/s00011-022-01661-4.
Jacobs CA, Olsen ZM, Marchand LS, Kraus VB, Anderson DD, Haller J. The Inflamma-type: a patient phenotype characterized by a dysregulated inflammatory response after lower extremity articular fracture. Inflamm Res. 2023 Jan;72(1):9–11.
Published In
Inflamm Res
DOI
EISSN
1420-908X
Publication Date
January 2023
Volume
72
Issue
1
Start / End Page
9 / 11
Location
Switzerland
Related Subject Headings
- Synovial Fluid
- Phenotype
- Lower Extremity
- Immunology
- Cytokines
- Biomarkers
- 3202 Clinical sciences
- 1103 Clinical Sciences